Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic dissection of a complex trait
Autore:
Lin, JH; Hinrichs, A; Liu, KY; Bierut, L; Suarez, BK;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Div Psychiat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 iv Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 17, anno: 1999, supplemento:, 1
pagine: S633 - S638
SICI:
0741-0395(1999)17:<S633:GDOACT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEQUILIBRIUM;
Keywords:
affected sib pairs; genexenvironment interaction; multipoint linkage analysis; transmission/disequilibium test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, JH Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 iat, St Louis, MO 63110 USA
Citazione:
J.H. Lin et al., "Genetic dissection of a complex trait", GENET EPID, 17, 1999, pp. S633-S638

Abstract

A number of genetic and statistical tools were applied to various partitions of the simulated data to identify susceptibility loci, relevant environmental factors, and their interaction(s). The distribution of genotypes at D1G24 among affected children in the first population was found to differ significantly from Hardy-Weinberg expectation. Two transmission/disequilibrium tests identified the preferential transmission of allele I as the source of the disequilibrium. Simple contingency table analysis revealed a positive association between exposure to environmental factor E1 and disease phenotype. Multipoint linkage analyses on various subsets of the data identifiedthree "signal" regions (in addition to the aforementioned D1G24) localizedat D1G9-10, D3G45, and D5G38. The even numbered chromosomes appeared to bedevoid of susceptibility loci. Further analyses of subsamples of affected sib pairs, selected according to their disease phenotype and their exposureto E1, clarified some linkage relationships, particularly for D3G45, thereby suggesting the presence of a specific genexenvironment interaction. Logistic analysis designed to clarify the relationship between disease phenotype and two risk factors (E1 exposure and the presence of allele 1 at D1G24) in the first population, revealed a significantly negative interaction which, upon learning the details of the generating model, we now attribute to the presence of heterogeneity. ((C)) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:47:46