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Titolo:
Markov chain Monte Carlo linkage analysis of a complex qualitative phenotype
Autore:
Hinrichs, A; Lin, JH; Reich, T; Bierut, L; Suarez, BK;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 17, anno: 1999, supplemento:, 1
pagine: S615 - S620
SICI:
0741-0395(1999)17:<S615:MCMCLA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Keywords:
linkage; quantitative trait linkage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
1
Recensione:
Indirizzi per estratti:
Indirizzo: Hinrichs, A Washington Univ, Sch Med, Dept Psychiat, 4940 Childrens Pl, StLouis, MO 63110 USA Washington Univ 4940 Childrens Pl St Louis MO USA 63110 10 USA
Citazione:
A. Hinrichs et al., "Markov chain Monte Carlo linkage analysis of a complex qualitative phenotype", GENET EPID, 17, 1999, pp. S615-S620

Abstract

We tested a new computer program, LOKI, that implements a reversible jump Markov chain Monte Carlo (MCMC) technique for segregation and linkage analysis. Our objective was to determine whether this software, designed for usewith continuously distributed phenotypes, has any efficacy when applied tothe discrete disease states of the simulated data from the Mordor data from GAW Problem 1. Although we were able to identify the genomic location fortwo of the three quantitative trait loci by repeated application of the software, the MCMC sampler experienced significant mixing problems indicatingthat the method, as currently formulated in LOKI, was not suitable for thediscrete phenotypes in this data set. ((C)) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 22:14:35