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Titolo:
A logistic regression extension of the transmission disequilibrium test for continuous traits: Application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3
Autore:
Waldman, ID; Robinson, BF; Rhee, SH;
Indirizzi:
Emory Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA30322 Univ, Dept Psychol, Atlanta, GA 30322 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 17, anno: 1999, supplemento:, 1
pagine: S379 - S384
SICI:
0741-0395(1999)17:<S379:ALREOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR GENE; ASSOCIATION; DEPENDENCE;
Keywords:
association; correlated phenotypes; logistic regression; moderators;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Waldman, ID Emory Univ, Dept Psychol, 532 N Kilgo Circle, Atlanta, GA 30322 USA Emory Univ 532 N Kilgo Circle Atlanta GA USA 30322 A 30322 USA
Citazione:
I.D. Waldman et al., "A logistic regression extension of the transmission disequilibrium test for continuous traits: Application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3", GENET EPID, 17, 1999, pp. S379-S384

Abstract

The transmission disequilibrium test (TDT) recently has become a popular method of testing for linkage in the presence of association due to its simplicity and advantages over other within-family analytic methods. In this paper, we describe a logistic regression extension to the TDT that can be used to test for differences in linkage disequilibrium as a function of one ormore continuous and/or categorical explanatory variables. We highlight important features of this method and demonstrate some of its possible uses. We applied these analyses to test for linkage disequilibrium between the dopamine receptor D2 (DRD2) and alcohol dehydrogenase 3 (ADH3) genes and both diagnostic and quantitative indices of alcoholism Using data from the Collaborative Study on the Genetics of Alcoholism data set, we found evidence suggesting linkage disequilibrium between DRD2 and ADH3 and quantitative indices of alcoholism and correlated phenotypes corresponding to smoking and personality None of the evidence for linkage disequilibrium varied by sex or age. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 25/01/20 alle ore 15:50:30