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Titolo:
Brain event-related potentials, dopamine D2 receptor gene polymorphism, and smoking
Autore:
Anokhin, AP; Todorov, AA; Madden, PAF; Grant, JD; Heath, AC;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63108 USA WashingtonUniv St Louis MO USA 63108 pt Psychiat, St Louis, MO 63108 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 17, anno: 1999, supplemento:, 1
pagine: S37 - S42
SICI:
0741-0395(1999)17:<S37:BEPDDR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLONGED P300 LATENCY; A1 ALLELE; DRD2 GENE; ASSOCIATION; ALCOHOLISM; CHILDREN; NICOTINE; RISK;
Keywords:
dopamine receptor gene; genetic association; P300;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Anokhin, AP Washington Univ, Sch Med, Dept Psychiat, 40N Kingshighway,Suite 1, St Louis, MO 63108 USA Washington Univ 40N Kingshighway,Suite 1 St Louis MO USA 63108
Citazione:
A.P. Anokhin et al., "Brain event-related potentials, dopamine D2 receptor gene polymorphism, and smoking", GENET EPID, 17, 1999, pp. S37-S42

Abstract

This paper explores the relationship between the DRD2 gene polymorphism, P300, and smoking. Both smoking and DRD2 have significant reducing effects on P300 amplitude. The effect of smoking is apparent only in the presence ofthe Al allele of the DRD2 locus. Transmission/disequilibrium analyses showa negative association between the A2 allele and smoking initiation, suggesting a protective effect of this allele. When the sample is stratified into lower- and higher-P300 categories, we find a significant association between Al and current smoking only in individuals with tower P300. Both concordance for smoking and DRD2 genotype are significant predictors of sib-pair similarity in P300 amplitude. These results suggest a synergistic effect ofdifferent neurogenetic risk factors contributing to nicotine dependence. Neurocognitive variation (P300) may moderate the association between DRD2 and smoking. Alternatively, DRD2 genotype may modulate the long-term impact of nicotine on neurocognitive functioning. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:46:15