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Titolo:
Detection of aromatase cytochrome P-450 in endometrial biopsy specimens asa diagnostic test for endometriosis
Autore:
Kitawaki, J; Kusuki, I; Koshiba, H; Tsukamoto, K; Fushiki, S; Honjo, H;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med, Dept Dynam Pathol, Res Inst Neurol Dis & Geriatr, Kyoto, Japan Kyoto Prefectural Univ Med Kyoto Japan urol Dis & Geriatr, Kyoto, Japan
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 6, volume: 72, anno: 1999,
pagine: 1100 - 1106
SICI:
0015-0282(199912)72:6<1100:DOACPI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN UTERINE LEIOMYOMA; STROMAL CELLS; NEOPLASTIC ENDOMETRIUM; ADENOMYOTIC TISSUES; ESTROGEN SYNTHESIS; EXPRESSION; ANDROSTENEDIONE; GLANDS; GENE;
Keywords:
endometriosis; adenomyosis; leiomyomas; infertility; aromatase cytochrome P-450; estrogen; endometrial biopsy; diagnostic test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kitawaki, J Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Kamigyo Ku,465 Kajii Cho, Kyoto 6028566, Japan Kyoto Prefectural Univ Med 465 Kajii Cho Kyoto Japan 6028566
Citazione:
J. Kitawaki et al., "Detection of aromatase cytochrome P-450 in endometrial biopsy specimens asa diagnostic test for endometriosis", FERT STERIL, 72(6), 1999, pp. 1100-1106

Abstract

Objective: To evaluate the clinical usefulness of examining endometrial biopsy specimens for aromatase cytochrome P-450 as a diagnostic test for endometriosis. Design: Retrospective, case-controlled study. Setting: Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto, Japan. Patient(s): One hundred five women of reproductive age with normal menstrual cycles underwent endometrial biopsy laparotomy or laparoscopy, and examination of their tissue revealed endometriosis, adenomyosis, and/or leiomyomas. Patients who had cervical carcinoma in situ but no other gynecologic disease were considered to be disease-free. Intervention(s): Endometrial biopsy specimens were collected. Main Outcome Measure(s): The expression of aromatase cytochrome P-450 was examined by reverse transcription-polymerase chain reaction and immunohistochemical analysis. The distribution and intensity of the immunostaining wasassessed using a semiquantitative index designed H-score. Result(s): Immunostaining for aromatase cytochrome P-450 was detected in biopsy specimens obtained from patients with endometriosis, adenomyosis, and/or leiomyomas but not in specimens obtained from disease-free patients (H-score <20), with a sensitivity and specificity of 91% and 100%, respectively. Conclusion(s): The expression of aromatase cytochrome P-450 in biopsy specimens of eutopic endometrium distinguishes between disease-free women and women with endometriosis, adenomyosis, and/or leiomyomas. This technique canbe used at outpatient infertility clinics as an initial screening procedure to rule out the presence of estrogen-dependent disease. (C) 1999 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:05:23