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Titolo:
Levels of vascular endothelial growth factor are elevated in patients withectopic pregnancy: is this a novel marker?
Autore:
Daniel, Y; Geva, E; Lerner-Geva, L; Eshed-Englender, T; Gamzu, R; Lessing, JB; Bar-Am, A; Amit, A;
Indirizzi:
Lis Matern Hosp, Sara Racine In Vitro Fertilizat Unit, Dept Obstet & Gynecol, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel Lis Matern Hosp Tel Aviv Israel IL-64239 Ctr, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel Chaim Sheba Med Ctr, Dept Clin Epidemiol, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Lis Matern Hosp, Cytokine Res Lab, Dept Oncol, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel Lis Matern Hosp Tel Aviv Israel IL-64239 Ctr, IL-64239 Tel Aviv, Israel
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 6, volume: 72, anno: 1999,
pagine: 1013 - 1017
SICI:
0015-0282(199912)72:6<1013:LOVEGF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE SERUM PROGESTERONE; MATERNAL SERUM; HUMAN PLACENTA; HUMAN TROPHOBLAST; HUMAN ENDOMETRIUM; ANGIOGENESIS; EXPRESSION; VEGF; METAANALYSIS; LOCALIZATION;
Keywords:
ectopic pregnancy; VEGF; beta-hCG; progesterone; implantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Amit, A Lis Matern Hosp, Sara Racine In Vitro Fertilizat Unit, Dept Obstet& Gynecol, Tel Aviv Sourasky Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, Israel Lis Matern Hosp 6 Weizman St Tel Aviv Israel IL-64239 viv, Israel
Citazione:
Y. Daniel et al., "Levels of vascular endothelial growth factor are elevated in patients withectopic pregnancy: is this a novel marker?", FERT STERIL, 72(6), 1999, pp. 1013-1017

Abstract

Objective: To determine serum levels of vascular endothelial growth factor(VEGF) and evaluate their capacity to serve as a marker for the diagnosis of ectopic pregnancy (EP). Design: Prospective, case-controlled study. Setting: A tertiary care center. Patient(s): Twenty women with EP, 10 women with normal intrauterine pregnancy, and 10 women with abnormal intrauterine pregnancy, all at comparable stages of gestation. Intervention(s): Serum samples were obtained from all women. Main Outcome Measure(s): All samples were analyzed for VEGF, progesterone,and beta-hCG by specific methods. Result(s): Women with EP had higher serum levels of VEGF than women with normal intrauterine pregnancy and women with abnormal intrauterine pregnancy(median levels, 226.8 pg/mL, 24.4 pg/mL, and 59.4 pg/mL, respectively). With a cutoff level of 200 pg/mL, serum VEGF could distinguish intrauterine from extrauterine pregnancy with a sensitivity of 60%, specificity of 90%, and positive predictive value of 86%. Conclusion(s): The increased serum VEGF levels in women with EP may facilitate this challenging diagnosis and reduce maternal morbidity and mortality. ((C)1999 by American Society for Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:58:28