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Titolo:
Gender differences in expression of organic cation transporter OCT2 rat kidney
Autore:
Urakami, Y; Nakamura, N; Takahashi, K; Okuda, M; Saito, H; Hashimoto, Y; Inui, K;
Indirizzi:
Kyoto Univ, Fac Med, Kyoto Univ Hosp, Dept Pharm,Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Dept Pharm,Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 461, anno: 1999,
pagine: 339 - 342
SICI:
0014-5793(19991119)461:3<339:GDIEOO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-MEMBRANE VESICLES; FUNCTIONAL-CHARACTERIZATION; H+/PEPTIDE COTRANSPORTER; RENAL SECRETION; CLONING; LOCALIZATION; ANTIBIOTICS; MECHANISMS; BINDING; CORTEX;
Keywords:
organic cation transporter; tetraethylammonium; basolateral membrane; renal tubular secretion; (rat kidney);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Inui, K Kyoto Univ, Fac Med, Kyoto Univ Hosp, Dept Pharm,Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 rm,Sakyo Ku, Kyoto 6068507, Japan
Citazione:
Y. Urakami et al., "Gender differences in expression of organic cation transporter OCT2 rat kidney", FEBS LETTER, 461(3), 1999, pp. 339-342

Abstract

The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membrane vesicles of male rat kidney showed a higher transport activity for tetraethylammonium than those of female rat kidney. The expression levels of rOCT2 mRNA and protein in the kidney of males were much higher than those in females. There was no gender difference in mRNA expression of rOCT1 and rOCT3. These findings suggest that rOCT2 is responsible for the gender differences in renal basolateral membrane organic cation transport activity. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:57:22