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Titolo:
Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells
Autore:
Pirillo, A; Zhu, WM; Roma, P; Galli, G; Caruso, D; Pellegatta, F; Catapano, AL;
Indirizzi:
Univ Milan, Inst Pharmacol Sci, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 Inst Pharmacol Sci, I-20133 Milan, Italy Univ Milan, Ctr Studio Aterosclerosi, Milan, Italy Univ Milan Milan Italy iv Milan, Ctr Studio Aterosclerosi, Milan, Italy Ist Sci HS, Cardiovasc Physiopathol Lab, Milan, Italy Ist Sci HS Milan Italy ci HS, Cardiovasc Physiopathol Lab, Milan, Italy
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 462, anno: 1999,
pagine: 113 - 116
SICI:
0014-5793(19991126)462:1-2<113:OFOLAC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HEAT-SHOCK PROTEIN-70; SMOOTH-MUSCLE CELLS; ATHEROSCLEROTIC LESIONS; STRESS PROTEINS; CHOLESTEROL; OXIDATION; 7-KETOCHOLESTEROL; IDENTIFICATION; ATHEROGENICITY;
Keywords:
stress protein; 7-hydroxycholesterol; 7-hydroperoxycholeslerol; 7-ketocholesterol; 5,6-epoxycholesterol; 25-hydroxycholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Catapano, AL Univ Milan, Inst Pharmacol Sci, Via Balzaretti 9, I-20133 Milan, Italy Univ Milan Via Balzaretti 9 Milan Italy I-20133 Milan, Italy
Citazione:
A. Pirillo et al., "Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells", FEBS LETTER, 462(1-2), 1999, pp. 113-116

Abstract

Oxidized low density lipoprotein (OxLDL) possesses several proatherogenic characteristics, among which a marked cytotoxicity, In vitro, cytotoxicity of OxLDL to endothelial cells is associated with an increase in the expression of the inducible form of heat shock protein 70 (hsp70), generally regarded as a cytoprotective protein. Oxidized derivatives of cholesterol which form upon LDL oxidation are cytotoxic. Moreover, most of the OxLDL cytotoxicity is due to its lipid moiety, in particular to oxysterols, In this report we demonstrate that although oxysterols identified in OxLDL are cytotoxic, they cannot trigger the increase in hsp70 expression observed with intactoxidized lipoproteins. We speculate therefore that oxysterols may represent the most toxic form of oxidized lipids in LDL because they cannot activate a rescue mechanism (i.e, the hsp response) and may contribute significantly to cell death within atherosclerotic plaques. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:11:44