Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dopamine D-1 receptor-mediated control of striatal acetylcholine release by endogenous dopamine
Autore:
Acquas, E; Di Chiara, G;
Indirizzi:
Univ Cagliari, CNR, Ctr Neuropharmacol, Dept Toxicol, I-09126 Cagliari, Italy Univ Cagliari Cagliari Italy I-09126 pt Toxicol, I-09126 Cagliari, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 383, anno: 1999,
pagine: 121 - 127
SICI:
0014-2999(19991027)383:2<121:DDRCOS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; IN-VIVO; CHOLINERGIC INTERNEURONS; NUCLEUS; D1; D1-RECEPTOR; STIMULATION; MECHANISM;
Keywords:
acetylcholine; dopamine; microdialysis quinpirole; PD 128,907; SCH 39166; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Di Chiara, G Univ Cagliari, CNR, Ctr Neuropharmacol, Dept Toxicol, Via A Diaz 182, I-09126 Cagliari, Italy Univ Cagliari Via A Diaz 182 Cagliari Italy I-09126 i, Italy
Citazione:
E. Acquas e G. Di Chiara, "Dopamine D-1 receptor-mediated control of striatal acetylcholine release by endogenous dopamine", EUR J PHARM, 383(2), 1999, pp. 121-127

Abstract

The role of dopamine D-1 and D-2 receptors in the control of acetylcholinerelease in the dorsal striatum by endogenous dopamine was investigated by monitoring with microdialysis the effect of the separate or combined administration of the dopamine D-1 receptor antagonist, SCH 39166 {(-)-trans-6,7,7a,8,9,13b-exahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo-[d]-naphto-[2,1,b]-azepine hydrochloride} (50 mu g/kg subcutaneous (s.c.)), of the dopamine D-2/D-3 receptor agonist, quinpirole (trans-(-)-4aR,4a,5,6,7,8,8a,9-octohydro-5-propyl-1H-pyrazolo-(3,4-g)-quinoline hydrochloride) (5 and 10 mu g/kg s.c.), and of the D-3 receptor selective agonist, PD 128,907 [S(+)-(4aR,10bR)-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride] (50 mu g/kg s.c.), on in vivo dopamine and acetylcholine release. Microdialysis was performed with a Ringer containing low concentrations (0.01 mu M) of the acetylcholinesterase inhibitor, neostigmine. Quinpirole(10 mu g/kg s.c.) decreased striatal dopamine and acetylcholine release. Administration of PD 128,907 (50 mu g/kg) decreased dopamine but failed to affect acetylcholine release. SCH 39166 (50 mu g/kg s.c.) stimulated dopamine release and reduced acetylcholine release. Pretreatment with quinpirole reduced (5 mu g/kg s.c.) or completely prevented (10 mu g/kg s.c.) the stimulation of dopamine release elicited by SCH 39166 (50 mu g/kg s.c.); on the other hand, pretreatment with quinpirole (5 and 10 mu g/kg) potentiatedthe reduction of striatal acetylcholine release induced by SCH 39166 (50 mu g/kg s.c.). Similarly, pretreatment with PD 128,907 (50 mu g/kg) which prevented the increase of dopamine release induced by SCH 39166 (50 mu g/kg),potentiated the reduction of striatal acetylcholine transmission elicited by SCH 39166. Thus, pretreatment with low doses of quinpirole or PD 128,907influences in opposite manner the effect of SCH 39166 on striatal dopamineand acetylcholine release, counteracting the increase of dopamine release and potentiating the decrease in acetylcholine release. These results provide further evidence for the existence of a tonic stimulatory input of endogenous dopamine on striatal acetylcholine transmission mediated by dopamine D-1 receptors. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:39:35