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Titolo:
Observational study in adult hypopituitary patients with untreated growth hormone deficiency (ODA study). Socio-economic impact and health status
Autore:
Sanmarti, A; Lucas, A; Hawkins, F; Webb, SM; Ulied, A;
Indirizzi:
Hosp Univ Germans Trias & Pujol, Serv Endocrinol, Barcelona 08916, Spain Hosp Univ Germans Trias & Pujol Barcelona Spain 08916 elona 08916, Spain Hosp 12 Octubre, E-28041 Madrid, Spain Hosp 12 Octubre Madrid Spain E-28041 p 12 Octubre, E-28041 Madrid, Spain Hosp Santa Creu & Sant Pau, Barcelona, Spain Hosp Santa Creu & Sant Pau Barcelona Spain & Sant Pau, Barcelona, Spain Pharmacia & Upjohn Inc, Dept Med, Barcelona, Spain Pharmacia & Upjohn IncBarcelona Spain Inc, Dept Med, Barcelona, Spain
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 5, volume: 141, anno: 1999,
pagine: 481 - 489
SICI:
0804-4643(199911)141:5<481:OSIAHP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; BODY-COMPOSITION; GH DEFICIENCY; REPLACEMENT THERAPY; PERFORMANCE; PREVALENCE; ONSET; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sanmarti, A Hosp Univ Germans Trias & Pujol, Serv Endocrinol, Carretera Canyet S-N, Barcelona 08916, Spain Hosp Univ Germans Trias & Pujol Carretera Canyet S-N Barcelona Spain 08916
Citazione:
A. Sanmarti et al., "Observational study in adult hypopituitary patients with untreated growth hormone deficiency (ODA study). Socio-economic impact and health status", EUR J ENDOC, 141(5), 1999, pp. 481-489

Abstract

Objective: The aim of the present study was to assess the socio-economic impact at baseline and after one gear of follow-up of clinical and health status characteristics and laboratory tests of adult-onset GH deficiency (AGHD), a well-known clinical entity, in a large group of Spanish hypopituitarypatients with untreated AGHD. Design and Methods: A total of 926 eligible patients with GHD (GH less than or equal to 5 ng/ml after stimulation) and at least one further pituitaryhormone deficiency were retrospectively studied; 356 of these were followed for one year. Complete physical examination, IGF-I, lipid and routine biochemistry measurements and health-related quality of life (HRQoL) with the specific QoL-Assessment of Growth Hormone Deficiency in Adults (AGHDA) questionnaire were assessed at baseline and at 12 months in the prospective study. Health status and health-economic evaluation were measured by a specific questionnaire and a patient diary and compared with Spanish population study results. Results: Clinical characteristics and laboratory tests of AGHD showed a higher incidence of cardiovascular risk factors and mortality compared with the general population (hypercholesterolaemia in 29% vs 18% and hypertensionin 22.1% vs 14.9%). QoL-AGHDA scores for patients were significantly worse(P<0.01) and direct health costs were higher than in the general population. Conclusions: Hypopituitary GHD adults had more cardiovascular risk factors, higher mortality, worse HRQoL and higher absolute health costs than the general population in Spain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:25:29