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Titolo:
Elevated cellular immune response to human heat-shock protein-60 in schizophrenic patients
Autore:
Leykin, I; Spivak, B; Weizman, A; Cohen, IR; Shinitzky, M;
Indirizzi:
Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 Chem, IL-76100 Rehovot, Israel Ness Ziona Psychiat Hosp, Ness Ziona, Israel Ness Ziona Psychiat Hosp Ness Ziona Israel iat Hosp, Ness Ziona, Israel Geha Psychiat Hosp, Petah Tiqwa, Israel Geha Psychiat Hosp Petah Tiqwa Israel sychiat Hosp, Petah Tiqwa, Israel Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 unol, IL-76100 Rehovot, Israel
Titolo Testata:
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
fascicolo: 5, volume: 249, anno: 1999,
pagine: 238 - 246
SICI:
0940-1334(199910)249:5<238:ECIRTH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; 65-KILODALTON MYCOBACTERIAL ANTIGEN; JUVENILE CHRONIC ARTHRITIS; RHEUMATOID-ARTHRITIS; INTERLEUKIN-2 PRODUCTION; BEHCETS-DISEASE; STRESS PROTEINS; T-CELLS; NEGATIVE ASSOCIATION; ADJUVANT ARTHRITIS;
Keywords:
autoimmunity; autoantigen; heat shock protein-60; immune response; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Shinitzky, M Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 0 Rehovot, Israel
Citazione:
I. Leykin et al., "Elevated cellular immune response to human heat-shock protein-60 in schizophrenic patients", EUR ARCH PS, 249(5), 1999, pp. 238-246

Abstract

Heat shock protein-60 (HSP60) is implicated in several autoimmune diseasesas a triggering antigen. Based on the autoimmune hypothesis of schizophrenia, we examined cellular and humoral responses against HSP60 and a series of its peptide fragments with peripheral blood samples of schizophrenic patients and healthy subjects each of group size between 12 to 32 participants. The average stimulation indices of peripheral blood mononuclear cells (PBMC) to HSP60 were 3.17 +/- 0.36 (mean +/- SE) for schizophrenic patients and2.23 +/- 0.24 (mean +/- SE) for healthy subjects, with a significant difference between the groups (P = 0.0457). In parallel, 38 synthetic peptide fragments of HSP60, each of 18-21 amino acids, were tested for in vitro sensitization of PBMC. With one peptide (p32) the average stimulation index of PBMC from schizophrenic patients was significantly higher than that obtainedfor PBMC of control subjects (P = 0.0006). Comparing the cellular immune response to p32 between patients who were distinctive responders (n = 10) ornon-responders (n = 10) to neuroleptic treatment indicated a similar elevation of cellular response in these groups. Antibodies against HSP60 were screened by dot-blot and ELISA in the sera of the above blood samples. Titersof IgG and ISM against HSP60 were found to be of similar magnitude in schizophrenic patients and in controls. Titers of IgA against HSP60 were somewhat higher in the sera of schizophrenic patients in comparison to sera of control subjects (P = 0.0605).

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Documento generato il 03/04/20 alle ore 14:06:52