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Titolo:
The side effects of antithyroid drugs
Autore:
Cooper, DS;
Indirizzi:
Johns Hopkins Univ, Sch Med, Sinai Hosp Baltimore, Div Endocrinol, Baltimore, MD 21215 USA Johns Hopkins Univ Baltimore MD USA 21215 crinol, Baltimore, MD 21215 USA
Titolo Testata:
ENDOCRINOLOGIST
fascicolo: 6, volume: 9, anno: 1999,
pagine: 457 - 467
SICI:
1051-2144(199911/12)9:6<457:TSEOAD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; METHIMAZOLE-INDUCED AGRANULOCYTOSIS; INSULIN AUTOIMMUNE SYNDROME; PROPYLTHIOURACIL-INDUCED AGRANULOCYTOSIS; ANTINEUTROPHIL CYTOPLASMIC ANTIBODY; SEVERE APLASTIC-ANEMIA; INDUCED HEPATIC DAMAGE; GRAVES-DISEASE; CHOLESTATIC JAUNDICE; FULMINANT-HEPATITIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
130
Recensione:
Indirizzi per estratti:
Indirizzo: Cooper, DS Johns Hopkins Univ, Sch Med, Sinai Hosp Baltimore, Div Endocrinol, Baltimore, MD 21215 USA Johns Hopkins Univ Baltimore MD USA 21215 timore, MD 21215 USA
Citazione:
D.S. Cooper, "The side effects of antithyroid drugs", ENDOCRINOLO, 9(6), 1999, pp. 457-467

Abstract

Antithyroid drugs are a mainstay of therapy of hyperthyroidism, especiallywhen it is due to Graves' disease. Although antithyroid agents are generally safe, side effects may limit their usefulness in some patients. Side effects are classified as minor and major, based on their degree of morbidity. All side effects are more common at higher doses of methimazole (40 mg/dayor more), but there is no apparent dose relationship for propylthiouracil (PTU). The most common minor side effects include cutaneous eruptions, arthralgias, and gastrointestinal upset, which develop in up to 5% of patients at usual doses. Hair loss, sialadenitis, myopathy, and abnormalities of taste and smell also have been described. The common major side effects are agranulocytosis (frequency 0.1-0.4%) and frank polyarthritis. Severe systemicvasculitis or drug-induced lupus (often antineutrophil cytoplasmic antibody positive) are associated with PTU. Hepatic toxicity with methimazole is cholestatic in nature and not as severe as the potentially life threatening hepatocellular reactions that are seen with PTU. Hypoprothrombinemia and the insulin autoimmune syndrome are exceedingly rare major side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:42:44