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Titolo:
Impaired diurnal cardiac autonomic function in subjects with type 2 diabetes
Autore:
Yamamoto, M; Yamasaki, Y; Kodama, M; Matsuhisa, M; Kishimoto, M; Ozaki, H; Tani, A; Ueda, N; Iwasaki, M; Hori, M;
Indirizzi:
Osaka Univ, Sch Med, Dept Med 1, Suita, Osaka 565, Japan Osaka Univ SuitaOsaka Japan 565 Med, Dept Med 1, Suita, Osaka 565, Japan Osaka Police Hosp, Osaka, Japan Osaka Police Hosp Osaka JapanOsaka Police Hosp, Osaka, Japan Yao Municipal Hosp, Osaka, Japan Yao Municipal Hosp Osaka JapanYao Municipal Hosp, Osaka, Japan
Titolo Testata:
DIABETES CARE
fascicolo: 12, volume: 22, anno: 1999,
pagine: 2072 - 2077
SICI:
0149-5992(199912)22:12<2072:IDCAFI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POWER SPECTRAL-ANALYSIS; HEART-RATE-VARIABILITY; BLOOD-PRESSURE; NEUROPATHY; INTERVAL; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yamasaki, Y Osaka Univ, Sch Med, Dept Med 1, 2-2 Yamadaoka, Suita, Osaka 565, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 565 saka 565, Japan
Citazione:
M. Yamamoto et al., "Impaired diurnal cardiac autonomic function in subjects with type 2 diabetes", DIABET CARE, 22(12), 1999, pp. 2072-2077

Abstract

OBJECTIVE - To assess diurnal cardiac sympathetic and parasympathetic nerve functions in diabetic subjects with variable diabetic neuropathy,RESEARCH DESIGN AND METHODS - Frequency domain analysis of 24-h Holter ECGwas done for 132 diabetic subjects (84 without any symptomatic neuropathy;37 with only symptomatic peripheral neuropathy: 11 with symptomatic autonomic neuropathy) and 57 normal volunteers to calculate the low frequency (LF) component representing the beta-adrenoceptor function and the high frequency (HF) component: representing the cardiac parasympathetic nerve function. RESULTS - Cardiac LF and HF components in diabetic subjects without peripheral neuropathy showed values comparable to those of normal volunteers and a similar circadian rhythm, Diabetic subjects with peripheral neuropathy orautonomic neuropathy showed significantly depressed LF and HF components and loss of the circadian rhythm of LF and HF components compared with diabetic subjects without neuropathy Impairment of the LF component in the afternoon could be accounted for by the duration of diabetes and elevated HbA(1c) level. Impairment of the HF component at night could be accounted for by the duration of diabetes but not an elevated HbA(1c) level. CONCLUSIONS - These data indicated that diabetic subjects with peripheral neuropathy and diabetic subjects with symptomatic autonomic neuropathy, butnot diabetic subjects without neuropathy, showed a marked decrease in cardiac sympathetic and parasympathetic nerve functions and loss of circadian rhythm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:07:17