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Titolo:
Differentiation of the chick retinotectal topographic map by remodeling inspecificity and refinement in accuracy
Autore:
Ichijo, H;
Indirizzi:
Univ Tsukuba, Inst Basic Med Sci, Dept Anat, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 117, anno: 1999,
pagine: 199 - 211
SICI:
0165-3806(19991118)117:2<199:DOTCRT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GANGLION-CELL AXONS; MAMMALIAN RETINOCOLLICULAR PROJECTION; RECEPTOR ANTAGONISTS DISRUPT; RETINAL AXONS; VISUAL-SYSTEM; IN-VITRO; OPTIC TECTUM; GUIDANCE; ZEBRAFISH; EXPRESSION;
Keywords:
axonal guidance; retinotectal projection; retinal ganglion cell; growth cone; optic tectum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Ichijo, H Univ Tsukuba, Inst Basic Med Sci, Dept Anat, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 araki 3058575, Japan
Citazione:
H. Ichijo, "Differentiation of the chick retinotectal topographic map by remodeling inspecificity and refinement in accuracy", DEV BRAIN R, 117(2), 1999, pp. 199-211

Abstract

To understand the development of the retinotopic map, differentiation of the topographic map was quantitatively examined in the chick. Labeling the retinal ganglion cell (RGC) axons anterogradely with the local injections ofDiI revealed the relative anteroposterior positions of their growth cones (GCs) on the tecta as a function of the nasotemporal positions of the injected sites in the retinae, which allowed a graphic representation of the map. The topographic map was depicted by combination of two parameters: specificity which indicates strictness of the topographic relationship between locations of the RGC bodies and their GCs on the tectum, and accuracy which indicates an extent of the GC displacement on the tectum. A crude projectionwith low specificity emerged at embryonic day 11 (E11). The initial crude projection was remodeled into the inaccurate map with high specificity by E13; thereafter, it was refined to the accurate map with higher specificity by E15. The results suggest that the elements of the guidance mechanism operate stage by stage through the formation of the crude projection, the remodeling in specificity, and the refinement in accuracy to establish the final topographic map. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:03:12