Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The Age-Related Eye Disease Study (AREDS): Design implications AREDS report no. 1
Autore:
Kassoff, A; Kieval, S; Mehu, M; Buehler, J; Eglow, M; Kaufman, F; Margherio, RR; Cox, MS; Garretson, B; Hassan, T; Ruby, A; Trese, MT; Werner, JC; Williams, GA; Regan, V; Manatrey, P; Cumming, K; Zajechowski, M; Falk, R; Streasick, P; Szydlowski, L; Dreyer, RF; Ma, C; Beardsley, C; Crider, H; Capone, A; Aaberg, TM; Martin, D; Saperstein, D; Sternberg, P; Curtis, L; Stribling, B; Gilman, J; Myles, B; Swords, R; Orth, DH; Flood, TP; Civantos, J; deBustros, S; Packo, KH; MacLeod, C; Morrison, C; Bryant, DA; Doherty, D; Sandoval, S; Seddon, JM; Pinnolis, MK; Jones-Devonish, DA; Crouse, VD; Snow, KK; Evans, C; Davis, N; Callahan, C; Walsh, D; Dubois, J; Burton, I; Ferris, FL; Chew, EY; Csaky, K; McCarthy, SA; Dabas, KH; Goodman, L; Kim, YJ; Lopez, P; Mercer, R; Ayres, LM; LaRean, T; Randall, A; Chicca, M; Ciatto, PF; Kuehl, E; Kivitz, I; Koutsandreas, D; Friberg, TR; Eller, A; Gorin, MB; Alexander, J; Mack, B; Bressler, SB; Bressler, NM; Cassel, G; Goldberg, M; Haller, JA; Ratner, L; Schachat, AP; Sherman, SH; Sunness, JS; Schenning, S; Sackett, C; Cain, D; Emmert, D; George, T; Wheeler, S; Elman, MJ; Ballinger, R; Betancourt, A; Glasser, D; Lammlein, J; Seff, R; Shuman, M; Starr, J; Carrigan, A; Ringrose, C; Mathews, T; Sotirakos, P; Cain, T; Chandra, SR; Myers, FL; Nork, TM; Stevens, T; Blodi, B; Gottlieb, J; Perkins, T; Blatz, M; Walker, W; Harrison, B; Knutson, G; Krolnik, D; Somers, G; Davis, MD; Klein, BEK; Klein, R; Hubbard, L; Magli, YL; Brickbauer, J; Ansay, S; Armstrong, J; Neider, M; Wabers, H; Baliker, J; Kastorff, L; Laher, K; Badal, D; Geithman, PL; Miner, KD; King, WN; Osterly, KR; Dohm, KL; Onofrey, JA; Esser, B; Hurtenback, C; Fisher, MR; Robinson, NL; Reimers, J; Miller, D; Bowman, B; Gunter, E; Sowell, A; Lindblad, AS; Ederer, F; Milton, RC; Gensler, G; Anand, R; Entler, G; Stine, E; Berlin, SH; Scholl, PR; Mengers, SA; Ferris, FL; Chew, EY; Sperduto, R; Kurinij, N;
Indirizzi:
Devers Eye Inst, Portland, OR USA Devers Eye Inst Portland OR USADevers Eye Inst, Portland, OR USA Emory Univ, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322Emory Univ, Atlanta, GA 30322 USA Ingalls Mem Hosp, Harvey, IL USA Ingalls Mem Hosp Harvey IL USAIngalls Mem Hosp, Harvey, IL USA Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA Massachusetts Eye & Ear Infirm Boston MA USA 02114 , Boston, MA 02114 USA NEI, Ctr Clin, Bethesda, MD 20892 USA NEI Bethesda MD USA 20892NEI, Ctr Clin, Bethesda, MD 20892 USA Univ Pittsburgh, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 tsburgh, Pittsburgh, PA 15260 USA Johns Hopkins Med Inst, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 st, Baltimore, MD 21205 USA Univ Wisconsin, Reading Ctr, Madison, WI USA Univ Wisconsin Madison WI USA iv Wisconsin, Reading Ctr, Madison, WI USA Ctr Dis Control & Prevent, Cent Lab, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA vent, Cent Lab, Atlanta, GA USA NEI, Project Off, Bethesda, MD 20892 USA NEI Bethesda MD USA 20892NEI, Project Off, Bethesda, MD 20892 USA Natl Inst Hlth, Div Contracts & Grants, Bethesda, MD 20892 USA Natl Inst Hlth Bethesda MD USA 20892 cts & Grants, Bethesda, MD 20892 USA Bausch & Lomb Pharmaceut, Rochester, NY 14601 USA Bausch & Lomb Pharmaceut Rochester NY USA 14601 , Rochester, NY 14601 USA
Titolo Testata:
CONTROLLED CLINICAL TRIALS
fascicolo: 6, volume: 20, anno: 1999,
pagine: 573 - 600
SICI:
0197-2456(199912)20:6<573:TAEDS(>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY LIPOPROTEIN-CHOLESTEROL; SENILE MACULAR DEGENERATION; FAILURE TIME DATA; CARDIOVASCULAR-DISEASE; CLINICAL-TRIALS; BETA-CAROTENE; RISK-FACTORS; ZINC; SUPPLEMENTATION; MACULOPATHY;
Keywords:
age-related macular degeneration; cataract; clinical trial; clinical course; antioxidants; zinc; vitamin C; vitamin E; beta-carotene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Lindblad, AS EMMES Corp, AREDS Coordinating Ctr, 11325 7 Locks Rd,Suite 214, Potomac, MD 20854 USA EMMES Corp 11325 7 Locks Rd,Suite 214 Potomac MD USA 20854 SA
Citazione:
A. Kassoff et al., "The Age-Related Eye Disease Study (AREDS): Design implications AREDS report no. 1", CONTR CL TR, 20(6), 1999, pp. 573-600

Abstract

The Age-Related Eye Disease Study (AREDS) was initially conceived as a long-term multicenter, prospective study of the clinical course of age-relatedmacular degeneration (AMD) and age-related cataract. Data on progression rates and risk factors from the study will increase understanding of the clinical course of both conditions, generate hypotheses about etiology, and aid in the design of clinical trials of potential interventions. In addition to collecting natural history data, AREDS includes a clinical trial of high-dose vitamin and mineral supplements for AMD and a clinical trial of high-dose vitamin supplements for cataract. The clinical trials were initiated largely because of the widespread public use in the United States of commercially available pharmacologic doses of vitamins and minerals to treat thesetwo eye conditions and the absence of definitive studies on the safety andefficacy of their use. Important design issues for the clinical trials include: defining cataract and AMD, estimating event rates, determining the type and dosage of vitamins and minerals to be tested for each condition, andidentifying the parameters necessary for monitoring safety and efficacy. This paper describes the AREDS design, including the study rationale and operational structure, and the approach adopted to combine, for two diseases, clinical trials with a natural history study. (C) Elsevier Science Inc. 1999.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:17:26