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Titolo:
The receptor-mediated uptake, survival, replication, and drug sensitivity of Mycobacterium tuberculosis within the macrophage-like cell line THP-1: Acomparison with human monocyte-derived macrophages
Autore:
Stokes, RW; Doxsee, D;
Indirizzi:
British Columbias Childrens Hosp, Div Infect & Immunol Dis, Vancouver, BC V5Z 4H4, Canada British Columbias Childrens Hosp Vancouver BC Canada V5Z 4H4 4H4, Canada Canadian Bacterial Dis Network, Vancouver, BC V5Z 4H4, Canada Canadian Bacterial Dis Network Vancouver BC Canada V5Z 4H4 5Z 4H4, Canada Univ British Columbia, Dept Paediat, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada
Titolo Testata:
CELLULAR IMMUNOLOGY
fascicolo: 1, volume: 197, anno: 1999,
pagine: 1 - 9
SICI:
0008-8749(19991010)197:1<1:TRUSRA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ALVEOLAR MACROPHAGES; NECROSIS-FACTOR-ALPHA; CULTURED HUMAN MACROPHAGES; MONOCLONAL-ANTIBODIES; AVIUM COMPLEX; INTRACELLULARE COMPLEX; NONOPSONIC BINDING; TUBERCLE-BACILLI; GAMMA-INTERFERON; MURINE MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Stokes, RW BC Res Inst Childrens & Womens Hlth, 950 W 28th Ave,Room 304, Vancouver, BC V5Z 4H4, Canada BC Res Inst Childrens & Womens Hlth 950 W 28thAve,Room 304 Vancouver BC Canada V5Z 4H4
Citazione:
R.W. Stokes e D. Doxsee, "The receptor-mediated uptake, survival, replication, and drug sensitivity of Mycobacterium tuberculosis within the macrophage-like cell line THP-1: Acomparison with human monocyte-derived macrophages", CELL IMMUN, 197(1), 1999, pp. 1-9

Abstract

We have compared the interaction of Mycobacterium tuberculosis with the human macrophage-like cell line THP-1 and with human monocyte-derived macrophages (MDM). The association of M. tuberculosis with THP-1 and MDM was comparable in both the presence and the absence of serum. For both cells, serum-mediated binding was much greater than nonopsonic binding and was mediated by a heat-labile serum component. Nonopsonic binding of M. tuberculosis to both cells could be inhibited by antibodies recognizing CD11b and by mannanand glucan. Intracellular M. tuberculosis grew progressively in infected MDM and THP-1 cells. Treatment of the infected MDM and THP-1 cells with the anti-mycobacterial isoniazid resulted in the rapid killing of the intracellular mycobacteria. Differentiated, adherent THP-1 cells bound IgG and complement-coated particles at levels similar to those of MDM. However, binding of zymosan by THP-1 cells was significantly lower than that seen for MDM. (C) 1999 Academic Press.

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Documento generato il 27/09/20 alle ore 01:02:54