Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers
Autore:
Lee, SH; Shin, MS; Kim, HS; Lee, HK; Park, WS; Kim, SY; Lee, JH; Han, SY; Park, JY; Oh, RR; Jang, JJ; Han, JY; Lee, JY; Yoo, NJ;
Indirizzi:
Catholic Univ Korea, Coll Med, Dept Pathol, Socho Gu, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Catholic Univ Korea, Coll Med, Canc Res Inst, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 thol, Seoul 110799, South Korea Seoul Natl Univ, Coll Med, Canc Res Ctr, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 Ctr, Seoul 110799, South Korea
Titolo Testata:
CANCER RESEARCH
fascicolo: 22, volume: 59, anno: 1999,
pagine: 5683 - 5686
SICI:
0008-5472(19991115)59:22<5683:AOTDR2>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAIL-INDUCED APOPTOSIS; MELANOMA-CELLS; LIGAND TRAIL; HETEROZYGOSITY; CARCINOMA; REGIONS; 8P22;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Yoo, NJ Catholic Univ Korea, Coll Med, Dept Pathol, Socho Gu, 505 Banpodong, Seoul137701, South Korea Catholic Univ Korea 505 Banpodong Seoul South Korea 137701 Korea
Citazione:
S.H. Lee et al., "Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers", CANCER RES, 59(22), 1999, pp. 5683-5686

Abstract

Chromosome 8p21-22 is a frequent site of allelic deletions in menu types of human tumors, including non-small cell lung cancer (NSCLC), Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) is a cell-surface receptor involved in cell death signaling. The TRAIL-R2 gene recently has been mapped to chromosome 8p21-22. To explore the possibility that the TRAIL-R2 gene might be the relevant gene to the frequent deletion of 8p21-22 in NSCLC, we have analyzed the entire coding region and all splice sites of TRAIL-R2 for the detection of the somatic mutations in a series of 104 NSCLCs, Overall, 11 tumors (10.6%) were found to have TRAIL-R2 gene mutations in the death domain known to be invoiced in the transduction of an apoptotic signal. Our data indicate that somatic mutation of TRAIL-R2 map playa role in the pathogenesis of some NSCLCs and that the TRAIL-R2 gene is one of the genes relevant to the frequent loss of chromosome 8p21-22 in NSCLC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:12:01