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Titolo:
Septo-hippocampal drug interactions in post-trial memory processing
Autore:
Farr, SA; Uezu, K; Flood, JF; Morley, JE;
Indirizzi:
VA Med Ctr, Ctr Geriatr Res Educ & Clin, St Louis, MO USA VA Med Ctr St Louis MO USA Ctr Geriatr Res Educ & Clin, St Louis, MO USA St Louis Univ, Sch Med, Dept Internal Med, Div Geriatr Med, St Louis, MO 63106 USA St Louis Univ St Louis MO USA 63106 v Geriatr Med, St Louis, MO 63106 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 847, anno: 1999,
pagine: 221 - 230
SICI:
0006-8993(19991120)847:2<221:SDIIPM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; ASCENDING PROJECTIONS; MEDIAL SEPTUM; GABAERGIC NEURONS; RAT-BRAIN; AUTORADIOGRAPHIC ANALYSIS; INHIBITORY INTERNEURONS; CHOLINERGIC NEURONS; TEGMENTAL NUCLEUS; BASAL FOREBRAIN;
Keywords:
acetylcholine; aversive conditioning; gamma-aminobutyric acid; hippocampus; memory; mouse; retention; septum; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Farr, SA VA Med Ctr 151JC, 915 N Grand Blvd, St Louis, MO 63109 USA VA MedCtr 151JC 915 N Grand Blvd St Louis MO USA 63109 63109 USA
Citazione:
S.A. Farr et al., "Septo-hippocampal drug interactions in post-trial memory processing", BRAIN RES, 847(2), 1999, pp. 221-230

Abstract

To determine if serotonin and GABA regulate post-trial memory processing of the cholinergic projection from the septum to the hippocampus, mice were trained on footshock avoidance in a T-maze. Immediately after training, drugs were injected into the septum, hippocampus or both. Retention was tested1 week after training and drug administration. Ketanserin, a serotonin type 2 receptor antagonist at a dose of 0.5 ng, had no measurable effect on retention, but it reduced the dose of bicuculline, in the septum, or arecoline in the hippocampus that was needed to improve retention. DOI, a serotonintype 2 receptor agonist at a dose of 2.5 ng, had the opposite effect of increasing the doses of bicuculline and arecoline needed to improve retention. Bicuculline, a GABA(A) receptor antagonist at a dose of 0.1 pg, did not affect retention when injected alone into the septum, but it reduced the dose of arecoline needed to improve retention in the hippocampus. Muscimol, a GABA(A) receptor agonist at a dose of 5 ng, injected into the septum, increased the dose of arecoline needed to improve retention. The results of thisstudy are compatible with models that propose that serotonin innervation from the median raphe drives GABA interneurons in the medial septum that synapse on cholinergic neurons projecting to the hippocampus. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:14:28