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Titolo:
High-dose estrogen-induced osteogenesis in the mouse is partially suppressed by indomethacin
Autore:
Samuels, A; Perry, MJ; Tobias, JH;
Indirizzi:
Univ Bristol, Div Med, Rheumatol Unit, Bristol, Avon, England Univ Bristol Bristol Avon England Rheumatol Unit, Bristol, Avon, England
Titolo Testata:
BONE
fascicolo: 6, volume: 25, anno: 1999,
pagine: 675 - 680
SICI:
8756-3282(199912)25:6<675:HEOITM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; OSTEOBLASTIC CELLS; BONE-FORMATION; PROSTAGLANDIN PRODUCTION; MECHANICAL STIMULATION; ANABOLIC ACTIONS; MESSENGER-RNA; IN-VIVO; CALVARIAE; RATS;
Keywords:
estrogen; osteoblasts; mouse; indomethacin; prostaglandins; histomorphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Tobias, JH Bristol Royal Infirm, Rheumatol Unit, Bristol BS2 8HW, Avon, England Bristol Royal Infirm Bristol Avon England BS2 8HW von, England
Citazione:
A. Samuels et al., "High-dose estrogen-induced osteogenesis in the mouse is partially suppressed by indomethacin", BONE, 25(6), 1999, pp. 675-680

Abstract

We recently found that high-dose estrogen induces the formation of new sites of cancellous bone formation within the long bones of intact female mice. To examine whether prostaglandins play a role in mediating this response,we studied whether this is inhibited by coadministration of the cyclooxygenase inhibitor, indomethacin, Eight-week-old intact female mice were divided into four groups of ten, and administered vehicle, 17 beta-estradiol (E-2), at 500 mu g/animal per week and/or indomethacin at 2 mg/kg per day. Animals were killed after treatment for 24 days, and histomorphometric indices subsequently analyzed on longitudinal sections of the proximal tibial metaphysis, As found previously, E-2 treatment caused a striking increase in cancellous bone volume, associated with an equivalent increase in the extent of cancellous doubIelabeled surfaces, In mice treated with both indomethacinand E-2, significant reductions in cancellous bone volume and cancellous double-labeled surfaces were observed as compared with animals treated with E-2 alone, In contrast, indomethacin did not significantly influence these parameters when given alone, Subregional analysis within the proximal tibial metaphysis revealed that this inhibitory effect of indomethacin was more marked distally as compared with proximally, with the estrogen-induced gainin cancellous bone volume at these sites being reduced by 50% and 25%, respectively. We conclude that estrogen-induced osteogenesis in female mice ispartially suppressed by treatment with indomethacin, suggesting that prostaglandin synthesis plays a significant role in mediating this response, (C)1999 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:48:13