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Titolo:
Gangliosides are transported from the plasma membrane to intralysosomal membranes as revealed by immuno-electron microscopy
Autore:
Mobius, W; Herzog, V; Sandhoff, K; Schwarzmann, G;
Indirizzi:
Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany Kekule Inst Organ Chem & Biochem Bonn Germany D-53121 3121 Bonn, Germany Univ Bonn, Inst Zellbiol, D-53121 Bonn, Germany Univ Bonn Bonn Germany D-53121 onn, Inst Zellbiol, D-53121 Bonn, Germany
Titolo Testata:
BIOSCIENCE REPORTS
fascicolo: 4, volume: 19, anno: 1999,
pagine: 307 - 316
SICI:
0144-8463(199908)19:4<307:GATFTP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; MULTIVESICULAR ENDOSOMES; ACTIVATOR PROTEINS; RECEPTOR COMPLEXES; CELLS; LOCALIZATION; INTERNALIZATION; DEGRADATION; LYSOSOMES; TOPOLOGY;
Keywords:
biotin-GM1; immuno-electron microscopy; ganglioside transport; endocytosis; intralysosomal membranes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzmann, G Kekule Inst Organ Chem & Biochem, Gerhard Domagk Str 1, D-53121 Bonn, Germany Kekule Inst Organ Chem & Biochem Gerhard Domagk Str 1 Bonn Germany D-53121
Citazione:
W. Mobius et al., "Gangliosides are transported from the plasma membrane to intralysosomal membranes as revealed by immuno-electron microscopy", BIOSCI REP, 19(4), 1999, pp. 307-316

Abstract

A biotin-labeled derivative of the ganglioside GM1 (biotin-GM1) was used to study its transport along the endocytic pathway of cultured fibroblasts by immune-electron microscopy. Using electron dense endocytic tracers we could demonstrate that late endosomes and lysosomes of these cells are long living organelles with a high content of internal membranes. Our studies showthat during endocytosis the biotin-GM1 was transported to these intraendosomal and intralysosomal membranes. These observations support the hypothesis that glycosphingolipids (GSL) are preferentially degraded in intralysosomal vesicles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:26:43