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Titolo:
Endothelium-dependent relaxation of rabbit atherosclerotic aorta was not restored by control of hyperlipidemia: the possible role of peroxynitrite (ONOO-)
Autore:
Hayashi, T; Yamada, K; Esaki, T; Kano, H; Asai, Y; Thakur, NK; Jayachandran, M; Sumi, D; Iguchi, A;
Indirizzi:
Nagoya Univ, Sch Med, Dept Geriatr, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 147, anno: 1999,
pagine: 349 - 363
SICI:
0021-9150(199912)147:2<349:ERORAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE SYNTHASE; CORONARY-ARTERIES; SUPEROXIDE-DISMUTASE; RELEASE; CHOLESTEROL; MACROPHAGES; REGRESSION; ACETYLCHOLINE; MECHANISMS;
Keywords:
arteriosclerosis; hypercholesterolemia; immunohistochemistry; nitric oxide; peroxynitrite; regression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Hayashi, T Nagoya Univ, Sch Med, Dept Geriatr, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsuruma Cho Nagoya Aichi Japan 4668550 50, Japan
Citazione:
T. Hayashi et al., "Endothelium-dependent relaxation of rabbit atherosclerotic aorta was not restored by control of hyperlipidemia: the possible role of peroxynitrite (ONOO-)", ATHEROSCLER, 147(2), 1999, pp. 349-363

Abstract

We determined the role of ONOO- in nitric oxide (NO) mediated vascular response in atherosclerosis and regression following removal of dietary cholesterol. The effect of ONOO- on NO-mediated vascular responses was examined in vitro. Basal and stimulated NO release was estimated by an NO-selective electrode as well as vascular response and the plasma NO metabolites. An immunohistochemical study was also carried out. Responses were compared in normal controls, atherosclerotic rabbits fed 1% cholesterol diet for 6 or 9 weeks (atherosclerotic group) and animals fed a normal diet for 6-36 weeks after the high cholesterol diet for 6 or 9 weeks (regression group). ONOO- impaired the basal and acetylcholine-stimulated NO release, but did not affect endothelium-independent relaxation. After 15 weeks on a normal diet, the acetylcholine-stimulated and basal NO-mediated relaxation, which was diminished in the aorta induced by 6 weeks high cholesterol diet, became restored. However, the vascular response in the 9 weeks high cholesterol diet groupdid not return to normal after 36 weeks on a normal diet, iNOS was observed in atherosclerotic plaques in atherosclerotic and regression groups alongwith ONOO- in the 9 weeks high cholesterol diet group, but not in the 6 weeks group. Conclusively, ONOO- can play a role in impairment of NO-mediatedvascular response during the regression of dietary cholesterol-induced atherosclerosis, not in the initiation of atherosclerosis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:46:13