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Titolo:
Molecular targets of gene therapy
Autore:
Das, DK; Engelman, RM; Maulik, N; Rousou, JA; Flack, JE; Deaton, DW;
Indirizzi:
Univ Connecticut, Sch Med, Dept Surg, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 t Surg, Farmington, CT 06030 USA Baystate Med Ctr, Dept Surg, Springfield, MA 01107 USA Baystate Med Ctr Springfield MA USA 01107 Surg, Springfield, MA 01107 USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 5, volume: 68, anno: 1999,
pagine: 1929 - 1933
SICI:
0003-4975(199911)68:5<1929:MTOGT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-BINDING-PROTEIN; MYOCARDIAL REPERFUSION INJURY; PERFORATED BALLOON CATHETER; FREE-RADICAL SCAVENGERS; IN-VIVO; ISCHEMIA-REPERFUSION; RAT-HEART; PHOSPHOLIPASE INHIBITOR; GLUTATHIONE-PEROXIDASE; ADENOVIRAL VECTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Das, DK Univ Connecticut, Sch Med, Dept Surg, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 Farmington, CT 06030 USA
Citazione:
D.K. Das et al., "Molecular targets of gene therapy", ANN THORAC, 68(5), 1999, pp. 1929-1933

Abstract

Ischemic reperfused heart represents a potential target for gene therapy because gene transfer can represent an alternate pharmacological approach toprotect the heart from cellular injury. Gene therapy may be particularly useful to deal with previously unapproachable problems. For myocardial preservation, gene therapy could replace those pharmacological interventions when drugs are delivered locally by sustained release with the help of mechanical device, eg, implants. In this review, attempts are made to define the molecular targets for gene therapy primarily applicable to myocardial preservation associated with ischemia and reperfusion. It has been emphasized that for successful gene transfer, not only characterization of proper targetsand elimination of undesirable side effects are necessary, but also the therapy must be proven superior compared to other pharmacological interventions including surgery. (C) 1999 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:49:39