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Titolo:
H-1-receptor antagonists: safety issues
Autore:
Simons, FER;
Indirizzi:
Univ Manitoba, Dept Pediat & Child Hlth, Allergy & Clin Immunol Sect, Winnipeg, MB R3T 2N2, Canada Univ Manitoba Winnipeg MB Canada R3T 2N2 ct, Winnipeg, MB R3T 2N2, Canada
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 5, volume: 83, anno: 1999,
pagine: 481 - 488
SICI:
1081-1206(199911)83:5<481:HASI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; DRIVING PERFORMANCE; TERFENADINE; CETIRIZINE; HYDROXYZINE; ASTEMIZOLE; ANTIHISTAMINES; ERYTHROMYCIN; LORATADINE; DRUGS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Simons, FER Childrens Hosp Winnipeg, Room AE101,820 Sherbrook St, Winnipeg, MB R3A 1R9, Canada Childrens Hosp Winnipeg Room AE101,820 Sherbrook St Winnipeg MB Canada R3A 1R9
Citazione:
F.E.R. Simons, "H-1-receptor antagonists: safety issues", ANN ALLER A, 83(5), 1999, pp. 481-488

Abstract

Histamine is an important neurotransmitter. Old (first-generation) H-1-receptor antagonists such as chlorpheniramine, diphenhydramine, or triprolidine produce histamine blockade at H-1-receptors in the central nervous system(CNS) and frequently cause somnolence or other CNS adverse effects. New (second generation) H-1-antagonists such as cetirizine, fexofenadine,and loratadine represent an advance in therapeutics; in manufacturers' recommended doses, they enter the CNS in smaller amounts, produce relatively little somnolence or other CNS adverse effects, and do not exacerbate the adverse CNSeffects of alcohol or other CNS-active chemicals. Two H-1-antagonists, astemizole and terfenadine, have been found to prolong the QTc interval and, rarely, to cause cardiac dysrhythmias after overdose or under other specificconditions. This has led to withdrawal of; regulatory approval for them. An H-1-antagonist absolutely free from adverse effects under all circumstances is not yet available for use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/18 alle ore 07:44:28