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Titolo:
Changes in nasal resistance and nasal geometry using pressure and acousticrhinometry in a feline model of nasal congestion
Autore:
McLeod, RL; Mingo, GG; Herczku, C; Corboz, MR; Ramos, SI; DeGennaro-Culver, F; Pedersen, O; Hey, JA;
Indirizzi:
Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA Schering Plough Corp Kenilworth NJ USA 07033 st, Kenilworth, NJ 07033 USA Univ Aarhus, Inst Environm & Occupat Med, Aarhus, Denmark Univ Aarhus Aarhus Denmark Inst Environm & Occupat Med, Aarhus, Denmark
Titolo Testata:
AMERICAN JOURNAL OF RHINOLOGY
fascicolo: 5, volume: 13, anno: 1999,
pagine: 375 - 383
SICI:
1050-6586(199909/10)13:5<375:CINRAN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC RHINITIS; AIR-FLOW RESISTANCE; GUINEA-PIGS; ANTIGEN; PATENCY; CAVITY; VASCULATURE; BLOCKAGE; DRUG; DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: McLeod, RL Schering Plough Corp, Res Inst, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA Schering Plough Corp 2015 Galloping Hill Rd Kenilworth NJUSA 07033
Citazione:
R.L. McLeod et al., "Changes in nasal resistance and nasal geometry using pressure and acousticrhinometry in a feline model of nasal congestion", AM J RHINOL, 13(5), 1999, pp. 375-383

Abstract

This is the first report describing the use and pharmacological characterization of nasal patency by both pressure rhinometry and acoustic rhinometry(AcR) in art experimental cat model of nasal congestion. In pressure rhinometry studies, aerosolized compound 48/80 (0.1-3.0%), a mast cell liberatorincreased nasal airway resistance (NAR) 1.2 +/- 0.6, 5.8 +/- 0.5 8.6 +/- 1.1 and 7.9 +/- 1.5 cmH(2)O . L/minute, respectively. Increases in NAR produced by compound 48/80 were associated with a 395% increase in histamine concentration found in the nasal lavage fluid Pretreatment with the alpha-adrenoreceptor agonist, phenylpropanolamine (PPA; 0.1-3.0 mg/kg, i.v.), and theNO synthetase inhibitor, N-G-nitro-L-arginine (L-NAME; 10 mg/kg, i.v.) attenuated the increases in NAR produced by compound 48/80 The histamine H-1 antagonist chlorpheniramine (1.0 mg/kg, i.v.) and the H-2 antagonist, ranitidine (1.0 mg/kg, i.v.) had no decongestant activity. Also without decongestant activity were the muscarinic antagonist atropine, the cyclooxygenase inhibitor indomethacin, and the 5-HT blocker methysergide. Aerosolized histamine (0.1-1.0%) also produced a close dependent increase in NAR. In studies using acoustic rhinometry (AcR), intranasal application of compound 48/80 (0.1-1.0%) elicited pronounced decreases in nasal cavity volumes and minimumcross-sectional area (A(max)). Pretreatment with PPA (3 mg/kg, i.v. or 10 mg/kg, p.o.) attenuated the decreases in nasal volume and A(max). The effects of topical intranasal histamine (0.1-1.0%) on nasal geometry were similar to compound 48/80. We conclude that the cat is a useful model for evaluating the pharmacological actions of potential nasal decongestants. Furthermore, we also conclude that AcR is a useful method for noninvasive assessmentof nasal patency in a preclinical setting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 06:52:41