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Titolo:
Induced sputum, eosinophilic bronchitis, and chronic obstructive pulmonarydisease
Autore:
Hargreave, FE; Leigh, R;
Indirizzi:
St Josephs Hosp, Firestone Reg Chest & Allergy Unit, Dept Med, Asthma Res Grp, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Hamilton ON Canada L8N 4A6 , Hamilton, ON L8N 4A6, Canada St Josephs Hosp, Dept Paediat, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Hamilton ON Canada L8N 4A6 , Hamilton, ON L8N 4A6, Canada McMaster Univ, Hamilton, ON L8S 4L8, Canada McMaster Univ Hamilton ON Canada L8S 4L8 iv, Hamilton, ON L8S 4L8, Canada
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 160, anno: 1999, supplemento:, S
pagine: S53 - S57
SICI:
1073-449X(199911)160:5<S53:ISEBAC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIR-FLOW LIMITATION; CHRONIC COUGH; INFLAMMATORY INDEXES; ASTHMATIC SUBJECTS; CATIONIC PROTEIN; HEALTHY-SUBJECTS; CELL COUNTS; EXACERBATIONS; PREDNISONE; SMOKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hargreave, FE St Josephs Hosp, Firestone Reg Chest & Allergy Unit, Dept Med, Asthma Res Grp, 50 Charlton Ave E, Hamilton, ON L8N 4A6, Canada St Josephs Hosp 50 Charlton Ave E Hamilton ON Canada L8N 4A6
Citazione:
F.E. Hargreave e R. Leigh, "Induced sputum, eosinophilic bronchitis, and chronic obstructive pulmonarydisease", AM J R CRIT, 160(5), 1999, pp. S53-S57

Abstract

The application of sputum induction and refined methods of sputum examination has provided the opportunity to examine cell and molecular markers of airway inflammation in asthma, COPD, and other airway diseases. The measurements are relatively noninvasive and can be applied safely, with care, even in more severe exacerbations of asthma and severe COPD. Induced sputum examination can be applied at random and repeatedly and gives results that are reproducible, valid, and responsive to changes in treatment. An eosinophilic bronchitis, defined as sputum eosinophilia, is typical of asthma but can also occur in patients with a chronic cough without asthma, and in some patients with COPD in whom the classic inflammatory response is neutrophilic without eosinophilia. When eosinophilia occurs in COPD, it has been considered to be the result of cigarette smoking but it may be due to other causes. The clinical importance of eosinophilic bronchitis is that it responds to treatment with corticosteroid. In contrast, there is increasing evidence that an absence of sputum eosinophilia is associated with steroid resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:05:37