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Titolo:
Can we predict which wheezy infants will continue to wheeze?
Autore:
Clough, JB; Keeping, KA; Edwards, LC; Freeman, WM; Warner, JA; Warner, JO;
Indirizzi:
Univ Southampton, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD 6 6YD, Hants, England
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 160, anno: 1999,
pagine: 1473 - 1480
SICI:
1073-449X(199911)160:5<1473:CWPWWI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD ASTHMA; NATURAL-HISTORY; ATOPIC DISEASE; BRONCHIAL RESPONSIVENESS; PROLIFERATIVE RESPONSES; SKIN-TEST; T-CELLS; CHILDREN; RISK; LIFE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Clough, JB Univ Southampton, Southampton Gen Hosp, Child Hlth Level G 803,Ctr Block,Tremona Rd, Southampton SO16 6YD, Hants, England Univ SouthamptonChild Hlth Level G 803,Ctr Block,Tremona Rd Southampton Hants England SO166YD
Citazione:
J.B. Clough et al., "Can we predict which wheezy infants will continue to wheeze?", AM J R CRIT, 160(5), 1999, pp. 1473-1480

Abstract

Early intervention strategies in infant wheezing will be dependent on the ability to predict persistence of disease. We undertook a prospective longitudinal study to determine which factors might be predictive for the persistence of wheeze. We examined a group of 107 children 3 to 36 mo of age withat least one atopic parent. Children were recruited within 12 wk of first wheeze. Factors assessed included: personal atopy (IgE > 1 SD above age-related normal and/or eczema and/or positive skin tests); parental atopy; number of siblings; age at first wheeze; sex; serum-soluble IL-2R; proliferation of peripheral blood mononuclear cells (PBMC) to beta-lactoglobulin and toD. pteronyssinus; production of IFN-gamma on stimulation of PBMC with beta-lactoglobulin and with D. pteronyssinus. A positive clinical outcome (child requiring prophylactic antiasthma treatment after 1 yr) was observed in 53 (49.5%) children. Predictor variables were assessed by univariate and multivariate logistic regression. Wheeze was more likely to be persistent in older, atopic children with biparental atopy. The model offering best prediction of persistent wheeze with least risk of including asymptomatic subjects was age at presentation + slL-2R. Trials of early intervention strategiesusing a logistic regression equation based on this model for patient recruitment can now be designed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 12:41:14