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Titolo:
Contribution of bradykinin B-1 and B-2 receptors in allergen-induced bronchial hyperresponsiveness
Autore:
Huang, TJ; Haddad, EB; Fox, AJ; Salmon, M; Jones, C; Burgess, G; Chung, KF;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med London England SW3 6LY gland Chang Gung Mem Hosp, Keelung, Taiwan Chang Gung Mem Hosp Keelung TaiwanChang Gung Mem Hosp, Keelung, Taiwan Novartis Inst Med Res, London, England Novartis Inst Med Res London England rtis Inst Med Res, London, England
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 160, anno: 1999,
pagine: 1717 - 1723
SICI:
1073-449X(199911)160:5<1717:COBBAB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY MICROVASCULAR LEAKAGE; MOUSE-ISOLATED TRACHEA; SMOOTH-MUSCLE CELLS; BROWN-NORWAY RATS; ASTHMATIC SUBJECTS; INDUCED BRONCHOCONSTRICTION; TISSUE KALLIKREIN; SUPEROXIDE ANIONS; B1 RECEPTORS; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, KF Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med Dovehouse St London England SW3 6LY
Citazione:
T.J. Huang et al., "Contribution of bradykinin B-1 and B-2 receptors in allergen-induced bronchial hyperresponsiveness", AM J R CRIT, 160(5), 1999, pp. 1717-1723

Abstract

Bradykinin (BK) is a peptide mediator generated at sites of inflammation and its effects are mediated through constitutively expressed B-2 receptor or through induction of B-1 receptors. We examined the role of these receptors in bronchial hyperresponsiveness (BHR). Brown-Norway rats sensitized with ovalbumin (OA) and AI(OH), intraperitoneally, were exposed 3 wk later to either saline or OA aerosol. B-1 receptor antagonist desArg(10)[Hoe140] (200 nmol/kg or 1 mu mol/kg, intraperitoneally) or B-2 receptor antagonist Hoe140 (200 nmol/kg, intraperitoneally) was administered 30 min before allergen exposure. Hoel40 had no effect on OA-induced BHR to acetylcholine (ACh) and bronchoalveolar lavage fluid (BALF) cellular profiles, but inhibited bronchoconstriction to BK (p < 0.04). At both doses, desArg(10)[Hoe140] dose-dependently inhibited allergen-induced BHR to ACh (p < 0.01), but had no effect on bronchoconstriction to BK or baseline ACh responsiveness. The inflammatory cells in BALF were not affected apart from reduced lymphocyte numbers at the highest dose. B-1 receptor mRNA expression measured by Northern analysis was increased after allergen exposure in sensitized lungs, with a peak at 2 to 6 h after exposure, whereas B-2 receptor mRNA expression remained unchanged. Newly induced BK B-1 receptors may be involved in allergen-induced BHR to ACh, whereas constitutive B-2 receptors mediate BK-induced bronchoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:47:21