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Titolo:
Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder
Autore:
Blumberg, HP; Stern, E; Ricketts, S; Martinez, D; de Asis, J; White, T; Epstein, J; Isenberg, N; McBride, PA; Kemperman, I; Emmerich, S; Dhawan, V; Eidelberg, D; Kocsis, JH; Silbersweig, DA;
Indirizzi:
Cornell Univ, Med Ctr, New York Hosp, Dept Psychiat, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Dept Psychiat, New York, NY 10021 USA NYU, Sch Med, N Shore Univ Hosp, Dept Neurol, Manhasset, NY USA NYU Manhasset NY USA , N Shore Univ Hosp, Dept Neurol, Manhasset, NY USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 12, volume: 156, anno: 1999,
pagine: 1986 - 1988
SICI:
0002-953X(199912)156:12<1986:RAOPCD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; MOOD DISORDERS; SCHIZOPHRENIA; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Blumberg, HP VA Connecticut Healthcare Syst, Dept Psychiat, 116A,950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst 116A,950 Campbell Ave W Haven CT USA 06516
Citazione:
H.P. Blumberg et al., "Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder", AM J PSYCHI, 156(12), 1999, pp. 1986-1988

Abstract

Objective: This study investigated prefrontal cortex function in the manicstate of bipolar disorder. Method: High-sensitivity [O-15]H2O positron emission tomography and a word generation activation paradigm were used to study regional cerebral blood flow in five manic and six euthymic individuals with bipolar disorder and in five healthy individuals. Results: Decreased right rostral and orbital prefrontal cortex activation during word generation and decreased orbitofrontal activity during rest were associated with mania. Conclusions: The data support the presence of rostral and orbital prefrontal dysfunction in primary mania. These findings, when seen in the context of the human brain lesion and the behavioral neuroanatomic literatures, may help to explain some of the neurobehavioral abnormalities characteristicof the manic state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 15:59:09