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Titolo:
Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta(1) protein in the prefrontal cortex of teenage suicide subjects
Autore:
Pandey, GN; Dwivedi, Y; Pandey, SC; Teas, SS; Conley, RR; Roberts, RC; Tamminga, CA;
Indirizzi:
Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Dept Psychiat, Chicago, IL 60612 USA Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA Maryland Psychiat Res Ctr Baltimore MD USA 21228 Baltimore, MD 21228 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 12, volume: 156, anno: 1999,
pagine: 1895 - 1901
SICI:
0002-953X(199912)156:12<1895:LPPCAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; DEPRESSED CHILDREN; CEREBRAL-CORTEX; SUBUNIT LEVELS; KINASE-C; BRAIN; ADOLESCENTS; BINDING; VICTIMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Pandey, GN Univ Illinois, Inst Psychiat, Dept Psychiat, 1601 W Taylor St, Chicago, IL60612 USA Univ Illinois 1601 W Taylor St Chicago IL USA 60612 IL60612 USA
Citazione:
G.N. Pandey et al., "Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta(1) protein in the prefrontal cortex of teenage suicide subjects", AM J PSYCHI, 156(12), 1999, pp. 1895-1901

Abstract

Objective: The enzyme phosphoinositide-specific phospholipase C (PI-PLC) is a component of the phosphoinositide signal transduction system. Other components of this system have been found to be abnormal in adults and adolescents who have committed suicide, and so the authors examined whether PI-PLCactivity and protein expression of PLC isozymes are abnormal in postmortembrains of teenage suicide subjects. Method: PI-PLC activity and protein expression of the PLC beta(1), delta(1), and gamma(1) isozymes were examined in Brodmann's areas 8 and 9 of postmortem brains obtained from 18 teenage suicide subjects and 18 matched comparison subjects. PI-PLC activity was determined by enzymatic assay, and protein expression of the PLC isozymes was determined by the Western blot technique. Results: Compared with the normalsubjects, the teenage suicide subjects had significantly lower PI-PLC activity and immunolabeling of the specific PLC beta(1) isozyme in both membrane and cytosol fractions of Brodmann's areas 8 and 9 combined (prefrontal cortex). There was also a significant correlation between PI-PLC activity andprotein levels of the PLC beta(1) isozyme in the brains of the teenage suicide subjects. There was no significant difference in PI-PLC activity or level of PLC beta(1) protein between the suicide subjects with a history of mental disorders and those with no history of mental disorders; however, both groups had significantly lower PI-PLC activity and expression of PLC beta(1) protein than the normal subjects. Conclusions: Low PI-PLC activity and expressed levels of the PLC beta(1) isozyme in postmortem brains of suicidesubjects may have clinical relevance in the pathophysiology of suicidal behavior.

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Documento generato il 25/11/20 alle ore 18:55:30