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Titolo:
Determinants of mechanical properties in the developing ovine thoracic aorta
Autore:
Wells, SM; Langille, BL; Lee, JM; Adamson, SL;
Indirizzi:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 Engn, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Obstet & Gynecol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 necol, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 obiol, Toronto, ON M5S 1A8, Canada Dalhousie Univ, Sch Biomed Engn, Halifax, NS M5G 1X5, Canada Dalhousie Univ Halifax NS Canada M5G 1X5 ngn, Halifax, NS M5G 1X5, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 277, anno: 1999,
pagine: H1385 - H1391
SICI:
0363-6135(199910)277:4<H1385:DOMPIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; COLLAGEN CROSS-LINKING; BLOOD-FLOW; RHEOLOGICAL PROPERTIES; LIVING CYTOPLASM; SMOOTH-MUSCLE; RAT SKIN; GROWTH; ACCUMULATION; TENSION;
Keywords:
elasticity; viscoelasticity; development; elastin; collagen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Adamson, SL Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Rm 138-P,600 Univ Ave, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Rm 138-P,600 Univ Ave Toronto ON Canada M5G 1X5
Citazione:
S.M. Wells et al., "Determinants of mechanical properties in the developing ovine thoracic aorta", AM J P-HEAR, 277(4), 1999, pp. H1385-H1391

Abstract

We previously reported changes in mechanical properties and collagen cross-linking of the ovine thoracic aorta during perinatal development and postnatal maturation, and we now report changes in biochemical composition (elastin, collagen, and DNA contents per mg wet wt) over the same developmental intervals. A comparison of results from the present and previous studies has yielded novel and important observations concerning the relationship between aortic mechanics and composition during maturation. Developmental changes in aortic incremental elastic modulus at low tensile stress (E-low) closely followed changes in relative elastin content (i.e., per mg wet wt). An 89% increase in E-low during the perinatal period was associated with a 69%increase in relative elastin content, whereas neither variable changed during postnatal life. Incremental elastic modulus at high tensile stress (E-high) did not change during the perinatal period but increased 88% during postnatal life. This pattern closely paralleled changes in collagen cross-linking index, which did not change perinatally but almost doubled postnatally. In contrast, relative collagen content (per mg wet wt) increased only slightly from fetal to adult life, a trend that was unrelated to aortic mechanics. Substantial, progressive decreases in measures of wall viscosity (pressure wave attenuation coefficient and viscoelastic phase angle) from fetal to adult life followed the pattern observed for relative DNA (smooth musclecell) content (per mg wet wt). Our findings suggest that accumulation of elastin per milligram wet weight contributes most to developmental changes in E-low, change in collagen cross-linking is the primary determinant of developmental changes in E-high, and cell accumulation contributes most to developmental changes in wall viscosity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:37:22