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Titolo:
Alterations in angiotensin II release and vascular reactivity in hypertensive men: A pilot study
Autore:
Gasic, S; Ratheiser, K; Wagner, O; Nowotny, P; Vierhapper, H; Waldhausl, W;
Indirizzi:
Univ Vienna, Dept Med 3, Div Endocrinol & Metab, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 crinol & Metab, A-1090 Vienna, Austria Univ Vienna, Dept Med 4, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 na, Dept Med 4, A-1090 Vienna, Austria Univ Vienna, Inst Med & Lab Diagnost, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & Lab Diagnost, A-1090 Vienna, Austria
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 11, volume: 12, anno: 1999,
parte:, 1
pagine: 1055 - 1062
SICI:
0895-7061(199911)12:11<1055:AIAIRA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE BLOOD-FLOW; COLD PRESSOR TEST; SKELETAL-MUSCLE; EUGLYCEMIC HYPERINSULINEMIA; HEALTHY-VOLUNTEERS; INSULIN RESISTANCE; EXOGENOUS INSULIN; ENDOTHELIAL-CELLS; GLUCOSE; HUMANS;
Keywords:
angiotensin II; endothelin-1; insulin-clamp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Gasic, S Univ Vienna, Dept Med 3, Div Endocrinol & Metab, Wahringer Gurtel18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 Austria
Citazione:
S. Gasic et al., "Alterations in angiotensin II release and vascular reactivity in hypertensive men: A pilot study", AM J HYPERT, 12(11), 1999, pp. 1055-1062

Abstract

Cold- and insulin-mediated release of angiotensin II (AII) and endothelin-l (ET-1), as well as vascular reactivity to exogenous ET-1 and to insulin, were compared in hypertensive and normotensive subjects. Peripheral vascular release of AII and of ET-1 was investigated in 10 hypertensive (H; 29.2 +/- 5.8 years) and 12 normotensive (N; 29.1 +/- 4.6 years) men in two separate trials. Net transfemoral balance of AII and of ET-1 was calculated from the respective Arterio-Venous (A-V) differences in plasma concentrations (PC) of the peptides and the regional plasma now (indocyanine-green dye method), both at baseline conditions and after a cold stimulus (immersion of one hand into ice water) in 7H and 6N, or during short-timehyperinsulinemia (hyperinsulinemic euglycemic clamp: biosynthetic human insulin, 1 mU/kg/min) in 7H and 7N. Moreover, hemodynamic changes to sequential exogenous ET-1 infusion (1, 2.5, 5, 10, 20, 40 ng/min) or during hyperinsulinemic clamp were studied in 7H and 6N and 7H and 7N, respectively. Baseline net-transfemoral balance of ET-1 and of AII were similar in the two subject groups. The cold stimulus provoked a similar increase in transfemoral ET-1 release in H and N (H: 257.0 +/- 31.7 to 526.2 +/- 393.7 pg/min;N: 280.2 +/- 112.7 to 524.0 +/- 393.7 pg/min, mean a SD, P < .05). In contrast, the cold-induced increase in transfemoral AII release was somewhat more pronounced in H than in N (H: 162.2 +/- 304.6 to 1081.7 +/- 1037.7 pg/min, P < .05; N: 83.9 +/- 166.3 to 317.6 +/- 187.8 pg/min, P < .02; maximum value H upsilon N P < .05). During the hyperinsulinemic clamp the PC of insulin increased from 5.8 +/- 2.8 to 69.1 +/- 15.5 mu U/mL in H and from 4.6 +/- 1.7 to 67.5 +/- 9.5 mu U/mL in N; P < .0005. Hyperinsulinemia induced a similar elevation of norepinephrine PC in H and N, but an increase in transfemoral ET-1 release in N only (219.7 +/- 161.2 to 512.2 +/- 279.0 pg/min, P < .02). In contrast, hyperinsulinemia increased transfemoral AII formation in H (730.4 +/- 554.3 to 1088.6 +/- 597.9 pg/min, P < .05), but not in N. Insulin-mediated vasodilation was observed only in N, whereas ET-1-inducedvasoconstriction was blunted in H. We conclude that the cold-induced increase in peripheral vascular release of AII is more pronounced in H than in N, whereas insulin provokes an increase in AII formation in hypertensives only. Moreover, insulin-mediated vasodilation and ET-1-dependent vasoconstriction are blunted in hypertensive subjects. (C) 1999 American Journal of Hypertension, Ltd.

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Documento generato il 09/04/20 alle ore 19:01:12