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Titolo:
Intracoronary serotonin release after high-pressure coronary stenting
Autore:
Leosco, D; Fineschi, M; Pierli, C; Fiaschi, A; Ferrara, N; Bianco, S; Longobardi, G; Pisani, E; Bravi, A; Rengo, F;
Indirizzi:
Univ Naples Federico II, Cattedra Geriatr, Fac Med, Ist Med Interna Cardiol & Chirurg Cardiovasc, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 vasc, I-80131 Naples, Italy Emodinamica Policl Scotte, Malattie Cardiovasc UO 2, Siena, Italy Emodinamica Policl Scotte Siena Italy tie Cardiovasc UO 2, Siena, Italy Univ Siena, Ist Farmacol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Siena, Ist Farmacol, I-53100 Siena, Italy Fdn Salvatore Maugeri, Terme, Italy Fdn Salvatore Maugeri Terme ItalyFdn Salvatore Maugeri, Terme, Italy
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 11, volume: 84, anno: 1999,
pagine: 1317 - 1322
SICI:
0002-9149(199912)84:11<1317:ISRAHC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC FLOW VARIATIONS; PLATELET DEPOSITION; BALLOON INJURY; ARTERIES; DOGS; VASOCONSTRICTION; ANGIOPLASTY; THROMBOXANE-A2; PROLIFERATION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Leosco, D Univ Naples Federico II, Cattedra Geriatr, Fac Med, Ist Med Interna Cardiol & Chirurg Cardiovasc, Via S Pansini 5, I-80131 Naples, Italy Univ Naples Federico II Via S Pansini 5 Naples Italy I-80131 ly
Citazione:
D. Leosco et al., "Intracoronary serotonin release after high-pressure coronary stenting", AM J CARD, 84(11), 1999, pp. 1317-1322

Abstract

It is known that platelet-derived serotonin at the site of coronary angioplasty induces an increase in coronary tone and plays a role in vasoconstriction after balloon angioplasty. The goal of the present investigation was to compare local release of serotonin with changes in coronary tone after coronary stenting and coronary angioplasty. Twenty patients with significant stenosis (greater than or equal to 50% diameter narrowing) of the left anterior descending coronary artery were referred to traditional coronary angioplasty (10 patients; group 1) or high-pressure coronary stenting (10 patients; group 2). An additional 16 patients with similar angiographic characteristics were referred to the coronary angioplasty group (8 patients; group la) or stenting group (8 patients; group 2a) after pretreatment with ketanserin. Serotonin plasma levels in coronary sinus and coronary cross-sectionalarea distal to the site of dilatation were measured before and after both revascularization procedures. In groups 1 and la, plasma serotonin levels in coronary sinus increased from basal values of 3.2 +/- 0.8 and 3.2 +/- 0.5ng/ml to 29.5 +/- 13 and 25.6 +/- 9 ng/ml after ballooning (p <0.001 vs baseline). In groups 2 and 2a, plasma serotonin levels in coronary sinus increased from basal values of 3.5 +/- 0.3 and 3.5 +/- 0.7 ng/ml to 114.6 +/- 34 and 113 +/- 29 ng/ml after scenting (p <0.001 vs baseline and vs postangioplasty values in groups 1 and 1a). Coronary cross-sectional area distal tothe site of dilatation significantly decreased after angioplasty in group 1 (from 4.33 +/- 0.4 to 3.32 +/- 0.3 mm(2) p <0.001), and after stenting ingroup 2 (from 4.27 +/- 1.3 to 2.86 +/- 0.2 mm(2); p <0.001 vs baseline, and p <0.02 vs values after coronary angioplasty in group 1). Pretreatment with ketanserin significantly reduced distal coronary vasoconstriction after angioplasty and stenting. It is concluded that the higher local serotonin release after coronary stenting may explain the more marked coronary constriction observed after prosthesis deployment with respect to traditional coronary angioplasty. Ketanserin is able to significantly attenuate the increase in distal coronary tone induced by both revascularization procedures. (C)1999 by Excerpta Medico, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:38:08