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Titolo:
Genetic association between chronic ethanol withdrawal severity and acoustic startle parameters in WSP and WSR mice
Autore:
Ponomarev, I; Crabbe, JC;
Indirizzi:
Oregon Hlth Sci Univ, Vet Affairs Med Ctr, Res Serv R&D 12, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 R&D 12, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Behav Neurosci, Alcohol Res Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 es Ctr, Portland, OR 97201 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 11, volume: 23, anno: 1999,
pagine: 1730 - 1735
SICI:
0145-6008(199911)23:11<1730:GABCEW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDIOGENIC-SEIZURE SUSCEPTIBILITY; PREPULSE INHIBITION; DEPENDENCE; ALCOHOL; RATS;
Keywords:
alcohol dependence; genetic animal model; curve-fitting; selected lines; acoustic startle response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ponomarev, I Oregon Hlth Sci Univ, Vet Affairs Med Ctr, Res Serv R&D 12, 3710 SW US VetHosp Rd, Portland, OR 97201 USA Oregon Hlth Sci Univ 3710 SW US Vet Hosp Rd Portland OR USA 97201
Citazione:
I. Ponomarev e J.C. Crabbe, "Genetic association between chronic ethanol withdrawal severity and acoustic startle parameters in WSP and WSR mice", ALC CLIN EX, 23(11), 1999, pp. 1730-1735

Abstract

Background: The present study examined the genetic association between chronic ethanol withdrawal severity and acoustic startle response (ASR) in replicated lines of mice selected for high (Withdrawal Seizure-Prone; WSP) andlow (Withdrawal Seizure-Resistant; WSR) susceptibility to handling-inducedconvulsions after withdrawal from chronic exposure to ethanol. Any differences on a nonselected (correlated) trait between the opposite-selected lines is strong evidence for pleiotropic effects of the genes fixed by selection. Methods: Naive WSP and WSR mice of both replicates were placed in startle chambers and exposed to a series of white noise stimuli of different intensities. Tn Experiment 1, two parameters [the maximal acoustic startle response (R-max), and the sound intensity necessary to produce 50% of the maximalstartle response (dB(50))] were obtained from a least-squares nonlinear regression by fitting data for each subject to a sigmoidal function that bestdescribed the relationship between sound intensity and mean ASR. Response habituation of WSP and WSR mice to a repeated acoustic stimulus of high intensity was examined in Experiment 2. Results: When ASR amplitude was plotted versus sound intensity, the sigmoid intensify-response curves of both WSP replicates were shifted to the right relative to the responses of WSR mice, which suggested decreased startle sensitivity in the WSP animals. Statistical analysis showed that naive WSP mice were less sensitive (higher dB(50)) to acoustic stimulation than Seizure-Resistant animals whereas R-max was similar for both lines. The selectedlines also differed in their responses to repeated acoustic stimulation, with WSP mice demonstrating greater habituation. Conclusion: Results of the present study suggest some common genetic mechanisms underlying behavioral responsiveness to acoustic stimulation and severity of ethanol withdrawal.

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Documento generato il 09/04/20 alle ore 11:38:39