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Titolo:
Diamox (R) challenge test to decide indications for cerebrospinal fluid shunting in normal pressure hydrocephalus
Autore:
Miyake, H; Ohta, T; Kajimoto, Y; Deguchi, J;
Indirizzi:
Osaka Med Coll, Dept Neurosurg, Takatsuki, Osaka 569, Japan Osaka Med Coll Takatsuki Osaka Japan 569 urg, Takatsuki, Osaka 569, Japan
Titolo Testata:
ACTA NEUROCHIRURGICA
fascicolo: 11, volume: 141, anno: 1999,
pagine: 1187 - 1193
SICI:
0001-6268(1999)141:11<1187:D(CTTD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; INTRACRANIAL-PRESSURE; LUMBAR DRAINAGE; RESISTANCE; ACETAZOLAMIDE; TOMOGRAPHY; TEMPORARY; OUTFLOW;
Keywords:
normal pressure hydrocephalus; Diamox (R); ventriculoperitoneal shunt; telemetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Miyake, H Osaka Med Coll, Dept Neurosurg, Daigakucho 2-7, Takatsuki, Osaka569, Japan Osaka Med Coll Daigakucho 2-7 Takatsuki Osaka Japan 569 9, Japan
Citazione:
H. Miyake et al., "Diamox (R) challenge test to decide indications for cerebrospinal fluid shunting in normal pressure hydrocephalus", ACT NEUROCH, 141(11), 1999, pp. 1187-1193

Abstract

Objective. The indications for cerebrospinal fluid (CSF) shunting in patients with normal pressure hydrocephalus (NPH) have not been established. Establishment of clear-cut indications for this procedure is essential to ensure cost-effective, and safe treatment. We report the usefulness of the Diamox(R) challenge test in evaluating indications for CSF shunting in patientswith NPH. Methods. Pre- and post-operative responses in cerebral blood flow (CBF) and intracranial pressure (ICP) to intravenous administration of Diamox(R) 1000 mg (Diamox(R) administration) were analysed in 41 patients with NPH who were treated by ventriculoperitoneal (VP) shunt with a programmable valve and an on-off Valve. Results. The preoperative response of ICP to Diamox(R) administration was more than 10 mmHg in most patients in whom the shunt was effective (shunt effective group), however, it was less than 10 mmHg in most patients in whomthe shunt was ineffective (shunt non-effective group). Furthermore, the postoperative response of ICP to Diamox(R) administration decreased to less than 10 mmHg in most patients in the shunt effective group. The increases inCBF in response to Diamox(R) administration were similar in the two groupsboth before and after placement of the VP shunt. Conclusion. Patients in whom ICP increased by more than 10 mmHg in response to Diamox(R) administration were regarded to have poor CSF circulation and to thus be candidates for CSF shunting. The Diamox(R) challenge test is asimple, safe procedure, useful in evaluating the response to treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 10:46:50