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Titolo:
Pathological and immunological findings of athymic nude and congenic wild type BALB/c mice experimentally infected with Neospora caninum
Autore:
Shibahara, T; Kokuho, T; Eto, M; Haritani, M; Hamaoka, T; Shimura, K; Nakamura, K; Yokomizo, Y; Yamane, I;
Indirizzi:
Minist Agr Forestry & Fisheries, Natl Inst Anim Hlth, Tsukuba, Ibaraki 305, Japan Minist Agr Forestry & Fisheries Tsukuba Ibaraki Japan 305 raki 305, Japan
Titolo Testata:
VETERINARY PATHOLOGY
fascicolo: 4, volume: 36, anno: 1999,
pagine: 321 - 327
SICI:
0300-9858(199907)36:4<321:PAIFOA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; TOXOPLASMA-GONDII; BOVINE NEOSPORA; APICOMPLEXA INFECTIONS; INTERFERON-GAMMA; PROTOZOA; VIRULENCE; CELLS;
Keywords:
athymic nude mice; congenic wild type mice; dissemination; interferon-gamma; JPA1; lethality; Neospora;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shibahara, T Minist Agr Forestry & Fisheries, Natl Inst Anim Hlth, Hokkaido Res Stn, Lab Comparat Pathol, Hitsujigaoka 4, Sapporo, Hokkaido 0620045, Japan Minist Agr Forestry & Fisheries Hitsujigaoka 4 Sapporo Hokkaido Japan0620045
Citazione:
T. Shibahara et al., "Pathological and immunological findings of athymic nude and congenic wild type BALB/c mice experimentally infected with Neospora caninum", VET PATH, 36(4), 1999, pp. 321-327

Abstract

Neospora is a cyst-forming coccidian parasite that causes abortions and neuromuscular disorders in a wide variety of mammals. Japanese bovine isolateJPA1 was inoculated intraperitoneally into BALB/c nu/ nu (athymic nude) and BALB/c (congenic wild type) female mice to examine the distribution of parasites and resistance mechanisms to Neospora infection. All the athymic nude mice died within 28 days after intraperitoneal injection of 2 x 10(5) JPA1 tachyzoites, whereas all the congenic wild type mice survived without exhibiting any clinical signs. Tachyzoites were identified in the uterus and pancreas and later spread to many other organs. Most tachyzoites identifiedin the necrotic foci were localized in the epithelium of the venules and capillaries. Nude mice developed high level of serum interferon-gamma and interleukin-6 as infection proceeded. Inflammatory response to Neospora infection might be mediated by Th1-type dependent cellular immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 10:27:35