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Titolo:
Adult respiratory distress syndrome-like disorders after allogeneic bone marrow transplantation.
Autore:
Takatsuka, H; Takemoto, Y; Okamoto, T; Fujimori, Y; Tamura, S; Wada, H; Okada, M; Kanamaru, A; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Kinki Univ, Sch Med, Dept Internal Med 3, Osaka 589, Japan Kinki Univ Osaka Japan 589 ch Med, Dept Internal Med 3, Osaka 589, Japan
Titolo Testata:
TRANSPLANTATION
fascicolo: 9, volume: 68, anno: 1999,
pagine: 1343 - 1347
SICI:
0041-1337(19991115)68:9<1343:ARDSDA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; CAPILLARY LEAK SYNDROME; G-CSF; FACTOR-ALPHA; LUNG INJURY; MONOCLONAL-ANTIBODY; PULMONARY TOXICITY; ENDOTHELIAL-CELLS; SERUM LEVELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Takatsuka, H Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
H. Takatsuka et al., "Adult respiratory distress syndrome-like disorders after allogeneic bone marrow transplantation.", TRANSPLANT, 68(9), 1999, pp. 1343-1347

Abstract

Background. Adult respiratory distress syndrome-like respiratory disordersare a serious, but uncommon, complication of bone marrow transplantation. Methods. We measured various cytokines in 2 patients with respiratory disorders and 11 patients without respiratory problems after allogeneic bone marrow transplantation. Results. The patients with respiratory disorders had elevated levels of interferon-gamma and interleukin-2 in the aplastic phase, and elevation of tumor necrosis factor-alpha intercellular adhesion molecule-1, and interleukin-8 at the time of leukocyte recovery. Both patients with respiratory disorders developed fever during the aplastic phase, whereas none of the patients without fever had respiratory disorders. Among patients who had fever during the aplastic phase but no respiratory disorders, there was no elevationof cytokines from the aplastic phase to the recovery phase. Conclusions. Respiratory disorders may occur after bone marrow transplantation when an inflammatory response during the aplastic phase stimulates cytokines that cause vascular endothelial damage and increases the levels of chemokines and adhesive molecules along with elevation of the leukocyte count.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:56:08