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Titolo:
LPS upregulates MHC class III-A expression in B lymphocytes at transcriptional and at translational levels
Autore:
Barrachina, M; Gonalons, E; Celada, A;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Fisiol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 Fisiol, E-08028 Barcelona, Spain Univ Barcelona, Funacio August Pi & Sunyer, Dept Fisiol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 Fisiol, E-08028 Barcelona, Spain
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 5, volume: 54, anno: 1999,
pagine: 461 - 470
SICI:
0001-2815(199911)54:5<461:LUMCIE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN MONONUCLEAR PHAGOCYTES; GENE-EXPRESSION; IFN-GAMMA; LIPOPOLYSACCHARIDE STIMULATION; MESSENGER-RNA; MOLECULES; CELLS; BETA; MACROPHAGES;
Keywords:
mRNA; polysome; protein synthesis; ribosome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Celada, A Univ Barcelona, Fac Biol, Dept Fisiol, Av Diagonal 645, E-08028 Barcelona,Spain Univ Barcelona Av Diagonal 645 Barcelona Spain E-08028 na,Spain
Citazione:
M. Barrachina et al., "LPS upregulates MHC class III-A expression in B lymphocytes at transcriptional and at translational levels", TISSUE ANTI, 54(5), 1999, pp. 461-470

Abstract

Major histocompatibility complex (MHC) class II molecules are expressed ina limited number of cell types, including B lymphocytes, dendritic cells and macrophages. Lipopolysaccharide (LPS) increases the surface expression of class II molecules in a murine B-cell line by inducing an increase in I-Aprotein and I-A mRNA levels. LPS does not modify the rate of mRNA degradation; therefore, the increase in mRNA is due to an increase in transcription. In addition, LPS increases the levels of I-A alpha protein, which correlates with an increase in ribosome loading for I-A alpha but not for I-A betamRNA after treatment with LPS. Interestingly, in non-induced cells, I-A alpha messenger RNA shows a significant peak of free mRNA. Therefore, LPS regulates the expression of MHC class II molecules at translational lever in Bcells, in addition to the transcriptional control. The actual mechanism implies changes of translation initiation rates, as shown by an increase ribosome loading in polysome gradients.

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Documento generato il 15/07/20 alle ore 05:32:28