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Titolo:
Patterns of brain activity in patients with epilepsy and depression
Autore:
Ring, HA; Acton, PD; Scull, D; Costa, DC; Gacinovik, S; Gacinovik, MR;
Indirizzi:
St Bartholomews & Royal London Sch Med, Dept Psychol Med, London E1, England St Bartholomews & Royal London Sch Med London England E1 don E1, England Univ Coll London, Sch Med, Inst Nucl Med, London W1, England Univ Coll London London England W1 ed, Inst Nucl Med, London W1, England Univ Coll London, Sch Med, Neurol Inst, London W1, England Univ Coll London London England W1 Med, Neurol Inst, London W1, England
Titolo Testata:
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
fascicolo: 7, volume: 8, anno: 1999,
pagine: 390 - 397
SICI:
1059-1311(199910)8:7<390:POBAIP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; CEREBRAL BLOOD-FLOW; PARKINSONS-DISEASE; EMISSION TOMOGRAPHY; POSITRON EMISSION; FRONTAL-LOBE; PHENOMENOLOGY; MELANCHOLIA; LATERALITY; HAPPINESS;
Keywords:
epilepsy; depression; SPECT; cerebral blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ring, HA St Bartholomews & Royal London Sch Med, Dept Psychol Med, London E1, England St Bartholomews & Royal London Sch Med London England E1 ngland
Citazione:
H.A. Ring et al., "Patterns of brain activity in patients with epilepsy and depression", SEIZURE-E J, 8(7), 1999, pp. 390-397

Abstract

Depression is a recognized feature of epilepsy. This study tested the hypothesis that depression arising in patients with epilepsy would be associated with decreased activity in brain regions previously demonstrated to be hypoperfused both in primary depression and in depression secondary to movement disorders. Two groups of patients with temporal lobe epilepsy were studied, one of which also met DSM IV criteria for a major depressive episode. All underwent a SPECT scan using the blood flow marker, Tc-99m-HMPAO. An automated voxel-based analysis demonstrated no regions of relatively decreasedactivity in the depressed compared with the non-depressed patients. Sites of relative hyperactivity in the depressed group were concentrated in the left hemisphere, particularly in dorsolateral prefrontal cortex, striatum, thalamus and temporo-parietal regions. Comparison of these data with normal population data revealed that in the depressed epilepsy group regional activities were within the normal range whilst corresponding results from the non-depressed group were below it. Depressed patients with epilepsy have cerebral regions with greater perfusion than non-depressed people with epilepsy, although they are not hyperperfused compared with normals. Our results suggest that depression in people with epilepsy may arise from a mechanism which differs from that underlying the development of depression in patientswith movement disorders. (C) 1999 BEA Trading Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:31:46