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Titolo:
A differential neural response to threatening and non-threatening negativefacial expressions in paranoid and non-paranoid schizophrenics
Autore:
Phillips, ML; Williams, L; Senior, C; Bullmore, ET; Brammer, MJ; Andrew, C; Williams, SCR; David, AS;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England GKT Sch Med, London SE5 8AF, England GKT Sch Med London England SE5 8AFGKT Sch Med, London SE5 8AF, England Inst Psychiat, Brain Anal Unit, London SE5 8AF, England Inst Psychiat London England SE5 8AF Anal Unit, London SE5 8AF, England Univ New England, Sch Psychol, Armidale, NSW 2351, Australia Univ New England Armidale NSW Australia 2351 rmidale, NSW 2351, Australia GKT Sch Med, London SE5 8AZ, England GKT Sch Med London England SE5 8AZGKT Sch Med, London SE5 8AZ, England
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 92, anno: 1999,
pagine: 11 - 31
SICI:
0925-4927(19991108)92:1<11:ADNRTT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-NAIVE PATIENTS; VISUAL SCAN PATHS; PERSECUTORY DELUSIONS; HUMAN AMYGDALA; AFFECT RECOGNITION; FACE RECOGNITION; IMAGE-ANALYSIS; EMOTION; DISGUST; ACTIVATION;
Keywords:
schizophrenia; delusions; persecutory; face; emotion; fMRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, ML Inst Psychiat, Dept Psychol Med, 103 Denmark Hill, London SE58AF, England Inst Psychiat 103 Denmark Hill London England SE5 8AF ngland
Citazione:
M.L. Phillips et al., "A differential neural response to threatening and non-threatening negativefacial expressions in paranoid and non-paranoid schizophrenics", PSYCH RES-N, 92(1), 1999, pp. 11-31

Abstract

Several studies have demonstrated impaired facial expression recognition in schizophrenia. Few have examined the neural basis for this; none have compared the neural correlates of facial expression perception in different schizophrenic patient subgroups. We compared neural responses to facial expressions in 10 right-handed schizophrenic patients (five paranoid and five non-paranoid) and five normal volunteers using functional Magnetic Resonance Imaging (fMRI). In three 5-min experiments, subjects viewed alternating 30-s blocks of black-and-white facial expressions of either fear, anger or disgust contrasted with expressions of mild happiness. After scanning, subjects categorised each expression. All patients were less accurate in identifying expressions, and showed less activation to these stimuli than normals. Non-paranoids performed poorly in the identification task and failed to activate neural regions that are normally linked with perception of these stimuli. They categorised disgust as either anger or fear more frequently than paranoids, and demonstrated in response to disgust expressions activation inthe amygdala, a region associated with perception of fearful faces. Paranoids were more accurate in recognising expressions, and demonstrated greateractivation than non-paranoids to most stimuli. We provide the first evidence for a distinction between two schizophrenic patient subgroups on the basis of recognition of and neural response to different negative facial expressions. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:03:08