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Titolo:
Biosynthesis of desosamine: Construction of a new macrolide carrying a genetically designed sugar moiety
Autore:
Borisova, SA; Zhao, LS; Sherman, DH; Liu, HW;
Indirizzi:
Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 t Chem, Minneapolis, MN 55455 USA Univ Minnesota, Dept Microbiol & Biol Proc, Inst Technol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 echnol, Minneapolis, MN 55455 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 1, volume: 1, anno: 1999,
pagine: 133 - 136
SICI:
1523-7060(19990715)1:1<133:BODCOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROPOLYSPORA-ERYTHRAEA; STREPTOMYCES-VENEZUELAE; GENE-CLUSTER; ANTIBIOTICS; RESISTANCE; BACTERIA; STRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Borisova, SA Univ Minnesota, Dept Chem, 207 Pleasant St SE, Minneapolis, MN 55455 USA Univ Minnesota 207 Pleasant St SE Minneapolis MN USA 55455 SA
Citazione:
S.A. Borisova et al., "Biosynthesis of desosamine: Construction of a new macrolide carrying a genetically designed sugar moiety", ORG LETT, 1(1), 1999, pp. 133-136

Abstract

[GRAPHICS]The appended sugars in macrolide antibiotics are indispensable to the biological activities of these important drugs. In an effort to generate a set of novel macrolide derivatives, we have created a new analogue of methymycin and neomethymycin, antibiotics produced by Streptomyces venezuelae, This analogue 15 carrying a different sugar, D-quinovose, instead of D-desosamine, was constructed by taking advantage of targeted gene deletion combined with a specific pathway-independent C-3 reduction capability of the wild type S. venezuelae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:06:01