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Titolo:
A one-pot, two-step synthesis of tetrahydro asterriquinone E
Autore:
Harris, GD; Nguyen, A; App, H; Hirth, P; McMahon, G; Tang, C;
Indirizzi:
SUGEN Inc, S San Francisco, CA 94080 USA SUGEN Inc S San Francisco CA USA94080 Inc, S San Francisco, CA 94080 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 3, volume: 1, anno: 1999,
pagine: 431 - 433
SICI:
1523-7060(19990812)1:3<431:AOTSOT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPERGILLUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, GD SUGEN Inc, 230 E Grand Ave, S San Francisco, CA 94080 USA SUGENInc 230 E Grand Ave S San Francisco CA USA 94080 4080 USA
Citazione:
G.D. Harris et al., "A one-pot, two-step synthesis of tetrahydro asterriquinone E", ORG LETT, 1(3), 1999, pp. 431-433

Abstract

Bis(indolyl)dihydroxyquinone 2, the tetrahydro analogue of naturally occurring 1a, was synthesized by a novel, expeditious route. The short synthesiswas accomplished by treating p-bromanil (3) with 2 equiv of indole 4 in the presence of cesium carbonate in acetonitrile at ambient temperature to provide a 1:1 mixture of the dibromo regioisomers 7 and 8, followed by hydrolysis of the mixture to afford 2, The synthetic compound 2 was found to inhibit the binding of the Grb2 adapter protein to tyrosine-phosphorylated EGF receptor (IC50 = 1.2 mu M).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:37:36