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Titolo:
Chronic psychosocial stress and antidepressant treatment in tree shrews: time-dependent behavioral and endocrine effects
Autore:
Kramer, M; Hiemke, C; Fuchs, E;
Indirizzi:
German Primate Ctr, Div Neurobiol, D-37077 Gottingen, Germany German Primate Ctr Gottingen Germany D-37077 D-37077 Gottingen, Germany Univ Mainz, Dept Psychiat, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 nz, Dept Psychiat, D-6500 Mainz, Germany
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 7, volume: 23, anno: 1999,
pagine: 937 - 947
SICI:
0149-7634(199911)23:7<937:CPSAAT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; TUPAIA-BELANGERI; GLUCOCORTICOID RECEPTOR; SOCIAL STRESS; MILD STRESS; RATS; DEPRESSION; DYNAMICS; CATECHOLAMINES; NOREPINEPHRINE;
Keywords:
clomipramine; social defeat; marking behavior; self-grooming; avoidance behavior; consumatory behavior; urinary cortisol; urinary norepinephrine; HPA-axis; adrenomedullary system; Tupaia belangeri;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, E German Primate Ctr, Div Neurobiol, Kellnerweg 4, D-37077 Gottingen, Germany German Primate Ctr Kellnerweg 4 Gottingen Germany D-37077 ermany
Citazione:
M. Kramer et al., "Chronic psychosocial stress and antidepressant treatment in tree shrews: time-dependent behavioral and endocrine effects", NEUROSCI B, 23(7), 1999, pp. 937-947

Abstract

Social defeat has been shown to cause a number of behavioral, physiological, and central nervous changes in male tree shrews. The present study was designed to assess: (i) a potential time lag in the occurrence of behavioralalterations (locomotor activity, self-grooming, marking behavior, food andwater intake, and avoidance behavior) after stress and long-term antidepressant treatment; and (ii) to investigate potential interactions between behavioral and endocrine variables (urinary cortisol and norepinephrine). Maletree shrews were submitted to chronic psychosocial stress for 39 days. In this paradigm, the stress-induced behavioral and endocrine alterations in subordinate animals are based exclusively on the central nervous interpretation of the continuos visual presence of the dominant conspecific. During the last 29 days of stress exposure, the tricyclic antidepressant clomipramine was administered daily to the subordinate animals (50 mg/kg, p.o). Results from this group were compared with three other experimental groups: one group was just stressed, one group received only clomipramine, and one grouponly vehicle. To determine the time-dependent effects of psychosocial stress;and clomipramine treatment, behavior was recorded immediately after and 9 h after daily social encounters. Depending on the observation time, significant differences between the effects of psychosocial stress and antidepressant treatment were found. Generally, the effect of stress on behavioral parameters tended to be less distinct immediately after the social encountercompared to the later observation time. Furthermore the drug had a time-dependent restorative influence on marking and grooming behavior, locomotor activity, avoidance behavior, as well as on urinary cortisol, and norepinephrine excretion. Correlation analysis revealed significant interdependenciesbetween locomotor activity, marking behavior, and avoidance behavior on 1 day with cortisol and norepinephrine quantified in the morning urine of thefollowing day. These findings indicate that experimental manipulations, stress, and psychotropic drug application have a time lag on bio-behavioral parameters which should be considered when studying animal behavior in response to stressors and/or to drug treatment. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:58:09