Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: An autoradiographic study
Autore:
Yamane, F; Tohyama, Y; Diksic, M;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Cone Lab Neurosurg Res, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Res, Montreal, PQ H3A 2B4, Canada Tokyo Womens Med Univ, Dept Neurosurg, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 eurosurg, Tokyo 1628666, Japan Asahikawa Med Coll, Dept Neurosurg, Asahikawa, Hokkaido 078, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 078 kawa, Hokkaido 078, Japan
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 12, volume: 24, anno: 1999,
pagine: 1611 - 1620
SICI:
0364-3190(199912)24:12<1611:AACDTH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHESIS INVIVO; TREATED RATS; DEXFENFLURAMINE; NEUROTOXICITY; TRYPTOPHAN; TERM; PROJECTIONS; MECHANISMS; TERMINALS; ISOMERS;
Keywords:
D-fenfluramine; alpha-[C-14]methyl-L-cryptophan; autoradiography; serotonin synthesis rate; tryptophan hydroxylase; dorsal raphe;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Diksic, M McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, ConeLab Neurosurg Res, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
F. Yamane et al., "Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: An autoradiographic study", NEUROCHEM R, 24(12), 1999, pp. 1611-1620

Abstract

The effects of acute and chronic treatments with D-fenfluramine on the regional rates of serotonin (5-hydroxy-tryptamine; 5-HT) synthesis were investigated using the alpha-[C-14]methyl-L-tryptophan (alpha-[C-14]MTrp) autoradiographic method. In the first series of experiments, acute D-fenfluramine treatment (5 mg/kg; i.p.) given 20 min before the tracer injection significantly (p < 0.05) decreased 5-HT synthesis in the dorsal raphe, and significantly (p < 0.05) increased the rates in the cerebral cortices and caudate nucleus, when compared to the rates in the control rats (saline treated). Ina second series of experiments, following a 7-day treatment with D-fenfluramine (5 mg/kg/day; i.p.), a significant (p < 0.05) decrease of 5-HT synthesis, in the dorsal raphe was observed, and significant (p < 0.05) increaseswere observed in the hypothalamus, the dorsal thalamus, the medial and lateral geniculate body and some brain stem regions (locus ceruleus, inferior and superior colliculus). No significant changes were observed in the cerebral cortices.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:29:27