Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prothrombin concentration in the cerebrospinal fluid is not altered in Alzheimer's disease
Autore:
Lewczuk, P; Wiltfang, J; Lange, M; Jahn, H; Reiber, H; Ehrenreich, H;
Indirizzi:
Max Planck Inst Expt Med, D-37075 Gottingen, Germany Max Planck Inst Expt Med Gottingen Germany D-37075 75 Gottingen, Germany Univ Gottingen, Dept Psychiat, Gottingen, Germany Univ Gottingen Gottingen Germany gen, Dept Psychiat, Gottingen, Germany Univ Gottingen, Dept Neurol, Gottingen, Germany Univ Gottingen GottingenGermany ingen, Dept Neurol, Gottingen, Germany Univ Gottingen, Neurochem Lab, Gottingen, Germany Univ Gottingen Gottingen Germany gen, Neurochem Lab, Gottingen, Germany Univ Hamburg, Dept Psychiat, Hamburg, Germany Univ Hamburg Hamburg Germany v Hamburg, Dept Psychiat, Hamburg, Germany
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 12, volume: 24, anno: 1999,
pagine: 1531 - 1534
SICI:
0364-3190(199912)24:12<1531:PCITCF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
THROMBIN; PRECURSOR; PROTEASES; PROTEIN; BLOOD;
Keywords:
prothrombin; ELISA; cerebrospinal fluid; blood-CSF barrier; Alzheimer; neurological disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ehrenreich, H Max Planck Inst Expt Med, Hermann Rein Str 3, D-37075 Gottingen, Germany Max Planck Inst Expt Med Hermann Rein Str 3 Gottingen GermanyD-37075
Citazione:
P. Lewczuk et al., "Prothrombin concentration in the cerebrospinal fluid is not altered in Alzheimer's disease", NEUROCHEM R, 24(12), 1999, pp. 1531-1534

Abstract

Prothrombin, known to be expressed in brain and to possess growth modulating properties, has been suggested to be involved in the pathogenesis of Alzheimer's disease (AD). We studied prothrombin concentration in lumbar CSF (L-CSF) in patients with AD (n = 25), neurologic disease controls (NDC; n = 33) covering a wide range of neurologic disorders, and subjects with Guillain-Barre syndrome (GBS; n = 4) as well as in samples of non-pathological ventricular CSF (V-CSF; n = 4). The results were evaluated with respect to CSF flow rate, as indicated by the albumin quotient (Q(Alb)) The concentrations of prothrombin in L-CSF in NDC (mean: 0.46 mg/l, range: 0.21-0.96), and AD (mean: 0.6 mg/l, range: 0.19-1.2) were in the normal range reported previously. Expectedly, prothrombin concentration in L-CSF of GBS was increased(mean: 6.3 mg/l, range: 2.3-9.7) corresponding to the increased Q(Alb) in this group (mean 54.6 x 10(-3), range: 17-88.1). The concentrations of bothprothrombin and albumin were 5.5-fold higher in L-CSF than in V-CSF (mean Q(Alb) : 1.1 x 10(-3), mean concentration of prothrombin: 0.088 mg/l). In conclusion, CSF prothrombin in all conditions evaluated here is exclusively derived from blood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:30:01