Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Entorhinal but not hippocampal or subicular lesions disrupt latent inhibition in rats
Autore:
Coutureau, E; Galani, R; Gosselin, O; Majchrzak, M; Di Scala, G;
Indirizzi:
ULP, CNRS, UMR 7521, Lab Neurosci Comportementales & Cognit, F-67000 Strasbourg, France ULP Strasbourg France F-67000 tales & Cognit, F-67000 Strasbourg, France
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 72, anno: 1999,
pagine: 143 - 157
SICI:
1074-7427(199911)72:3<143:EBNHOS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE-INDUCED ACTIVITY; INDUCED LOCOMOTOR-ACTIVITY; NUCLEUS-ACCUMBENS; EXCITOTOXIC LESIONS; IBOTENATE LESIONS; ELECTROLYTIC LESIONS; PREFRONTAL CORTEX; DOPAMINE RELEASE; NEURONAL LOSS; SCHIZOPHRENIA;
Keywords:
conditioned emotional response; entorhinal cortex; hippocampus; ibotenate; latent inhibition; locomotor activity; NMDA; schizophrenia; selective lesions; subiculum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Coutureau, E ULP, CNRS, UMR 7521, Lab Neurosci Comportementales & Cognit, 12 Rue Goethe, F-67000 Strasbourg, France ULP 12 Rue Goethe Strasbourg France F-67000 rasbourg, France
Citazione:
E. Coutureau et al., "Entorhinal but not hippocampal or subicular lesions disrupt latent inhibition in rats", NEUROBIOL L, 72(3), 1999, pp. 143-157

Abstract

Latent inhibition (LI) is the deficit of conditioning resulting from repeated nonreinforced preexposure to a conditioned stimulus before its pairing with an unconditioned stimulus. There are cumulative data showing that large lesions of the hippocampal formation disrupt LI. However, the effects of selective lesions of the different components of the hippocampal formation have never been directly addressed in the same study and conditioning paradigm. The first experiment of the present study aimed at investigating the effects of excitotoxic lesions of the hippocampus, subiculum, or entorhinal cortex on LI in an "off-baseline"-conditioned emotional response procedure. Hippocampus or subiculum lesions had no effect on either LI or conditioning. In contrast, entorhinal cortex lesions disrupted LI without modifying conditioning. In Experiment 2, locomotor activity in a novel environment was assessed in the same rats. Whereas lesions of hippocampus increased locomotor activity, lesions of the subiculum or the entorhinal cortex were devoid of effect. Although both LI and habituation to novel environmental cues arethought to involve interactions between the hippocampal formation and the mesolimbic pathway, these results indicate a functional dissociation between the hippocampus and the entorhinal cortex. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:09:30