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Titolo:
The amygdala modulates prefrontal cortex activity relative to conditioned fear
Autore:
Garcia, R; Vouimba, RM; Baudry, M; Thompson, RF;
Indirizzi:
Univ Bordeaux 1, Cognit Neurosci Lab, CNRS, UMR 5807, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 UMR 5807, F-33405 Talence, France Univ So Calif, Program Neurosci, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 eurosci, Los Angeles, CA 90089 USA
Titolo Testata:
NATURE
fascicolo: 6759, volume: 402, anno: 1999,
pagine: 294 - 296
SICI:
0028-0836(19991118)402:6759<294:TAMPCA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASOLATERAL AMYGDALA; DOPAMINE NEURONS; RAT; ORGANIZATION; PROJECTIONS; NUCLEUS; STRESS; NEUROENDOCRINE; RESPONSES; THALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia, R Univ Bordeaux 1, Cognit Neurosci Lab, CNRS, UMR 5807, Ave Fac, F-33405 Talence, France Univ Bordeaux 1 Ave Fac Talence France F-33405 Talence, France
Citazione:
R. Garcia et al., "The amygdala modulates prefrontal cortex activity relative to conditioned fear", NATURE, 402(6759), 1999, pp. 294-296

Abstract

Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner displayfear responses, such as freezing behaviour, when they hear the conditionedtone. Studies using amygdalectomized rats have shown that the amygdala is required for both the acquisition and expression of learned fear responses(1-3) Freezing to a conditioned tone is enhanced following damage, to the dorsal part of the medial prefrontal cortex(4), indicating that this area maybe involved in fear reduction, Here we show that prefrontal neurons reducetheir spontaneous activity in the presence of a conditioned aversive tone as a function of the degree of fear, The depression in prefrontal spontaneous activity is related to amygdala activity but not to the freezing response itself. These data indicate that, in the presence of threatening stimuli,the amygdala controls both fear expression and prefrontal neuronal activity. They suggest that abnormal amygdala-induced modulation of prefrontal neuronal activity may be involved in the pathophysiology of certain forms of anxiety disorder.

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Documento generato il 18/01/21 alle ore 16:18:48