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Titolo:
Insulin-induced vasodilatation of internal carotid artery
Autore:
Chaudhuri, A; Kanjwal, Y; Mohanty, P; Rao, S; Sung, BH; Wilson, MF; Dandona, P;
Indirizzi:
SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Diabet, Buffalo,NY 14209 USA SUNY Buffalo Buffalo NY USA 14209 York, Div Diabet, Buffalo,NY 14209 USA SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol, Buffalo, NY 14209 USA SUNY Buffalo Buffalo NY USA 14209 , Div Endocrinol, Buffalo, NY 14209 USA SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Cardiol, Buffalo, NY 14209 USA SUNY Buffalo Buffalo NY USA 14209 ork, Div Cardiol, Buffalo, NY 14209 USA Kaleida Hlth, Buffalo, NY USA Kaleida Hlth Buffalo NY USAKaleida Hlth, Buffalo, NY USA
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 11, volume: 48, anno: 1999,
pagine: 1470 - 1473
SICI:
0026-0495(199911)48:11<1470:IVOICA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE BLOOD-FLOW; FOCAL ISCHEMIA; BRAIN-DAMAGE; METABOLISM; OCCLUSION; TISSUES; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Dandona, P SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Diabet, 3 Gates Circle, Buffalo, NY 14209 USA SUNY Buffalo 3 Gates Circle Buffalo NY USA 14209 , NY 14209 USA
Citazione:
A. Chaudhuri et al., "Insulin-induced vasodilatation of internal carotid artery", METABOLISM, 48(11), 1999, pp. 1470-1473

Abstract

The increase in leg and forearm blood flow induced by insulin could be secondary to its metabolic effect on glucose uptake. We therefore investigatedwhether insulin causes vasodilation of the internal carotid artery, since the brain is not dependent on insulin for glucose uptake, to demonstrate that the vasodilatory effect of insulin is primary and independent of its metabolic effect. Internal carotid artery diameter was continuously monitored using a 7.5-MHz transducer linked to an Acuson XP10 ultrasonograph (Mountainview, CA) during infusion of 125 mt 10% dextrose mixed with 3 U regular insulin and 5 mmol potassium chloride over 1 hour. The internal carotid artery diameter increased progressively with time from a mean ol: 5.4 +/- 1 mm to 5.7 +/- 1 mm at 15 minutes, 5.9 +/- 1.1 mm at 30 minutes, 6 +/- 1.1 mm at45 minutes, and 6.1 +/- 1.1 mm at 60 minutes (P < .05), an increase of 13%over baseline. Glucose was maintained between 93 and 106 mg/dL, and insulin increased from 15 +/- 14 mu U/mL and was maintained between 34 and 47 mu U/mL. There was no change in mean arterial blood pressure (MABP) or heart rate during the infusion. We conclude that insulin dilates the internal carotid artery consistently at physiological concentrations, probably independently of glucose uptake by the brain. Alterations in this effect of insulin may be of relevance in the pathogenesis of abnormalities of cerebral blood flow in type 1 and type 2 diabetics as described by our group previously. Copyright (C) 1999 by W.B. Saunders Company.

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Documento generato il 23/10/20 alle ore 11:57:56