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Titolo:
Changes in fat cell size and in vitro lipolytic activity of abdominal and gluteal adipocytes after a one-year cross-sex hormone administration in transsexuals
Autore:
Elbers, JMH; de Jong, S; Teerlink, T; Asscheman, H; Seidell, JC; Gooren, LJG;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Endocrinol & Androl, Res Inst Endocrinol Reproduct & Metab, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Dept Clin Chem, Res Inst Endocrinol Reproduct & Metab, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 11, volume: 48, anno: 1999,
pagine: 1371 - 1377
SICI:
0026-0495(199911)48:11<1371:CIFCSA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADIPOSE-TISSUE METABOLISM; POSTMENOPAUSAL WOMEN; REGIONAL DIFFERENCES; LIPOPROTEIN-LIPASE; MEN; TESTOSTERONE; RESISTANCE; OBESE; EXPRESSION; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Asscheman, H Free Univ Amsterdam Hosp, Dept Endocrinol & Androl, Res Inst Endocrinol Reproduct & Metab, POB 7057, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
J.M.H. Elbers et al., "Changes in fat cell size and in vitro lipolytic activity of abdominal and gluteal adipocytes after a one-year cross-sex hormone administration in transsexuals", METABOLISM, 48(11), 1999, pp. 1371-1377

Abstract

We prospectively studied the effects of cross-sex hormone administration on fat cell size and in vitro lipolytic activity in subcutaneous abdominal and gluteal fat biopsies obtained from 19 male-to-female (M-F) transsexuals and 17 female-to-male (F-M) transsexuals. The amount of subcutaneous fat atthe abdominal and gluteal levels was quantified with the use of magnetic resonance imaging (MRI). Before cross-sex hormone administration. M-F transsexuals had less subcutaneous fat with smaller fat cells compared with F-M transsexuals, with a higher baseline in vitro lipolytic activity expressed as glycerol release per milligram of triglyceride (TG) in the abdominal region (P < .05). Before cross-sex hormone treatment, no differences in lipolytic activity stimulated with arterenol (ART), isoproterenol (ISO), or ISO + insulin (INS) were observed between groups or regions. After a 1-year treatment with estrogens and antiandrogens in M-F transsexuals, subcutaneous fatareas on MRI and fat cell size were increased (P < .001) and reductions were observed in the basal lipolytic activity of gluteal and abdominal fat biopsies (P < .05). Following administration of testosterone to F-M transsexuals, subcutaneous fat and fat cell size at the gluteal and abdominal depotswere decreased (P < .01) and basal lipolysis was increased significantly at the abdominal level (P < .05) but not at the gluteal level. In both M-F and F-M transsexuals, no effect of sex hormone administration was observed on stimulated lipolytic activities; In conclusion, regional sex differences in the amount of subcutaneous fat, adipocyte size, and in vitro basal lipolytic activity were demonstrated that could be largely reversed by cross-sexhormone treatment in adult subjects, providing evidence for their dependence on the sex steroid milieu. Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:38:24