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Titolo:
The effect of riluzole in amyotrophic lateral sclerosis: a study with cortical stimulation
Autore:
Desiato, MT; Palmieri, MG; Giacomini, P; Scalise, A; Arciprete, F; Caramia, MD;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Osped S Eugenio, I-00143 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00143 S Eugenio, I-00143 Rome, Italy IRCCS, Rome, Italy IRCCS Rome ItalyIRCCS, Rome, Italy Univ Rome La Sapienza, Neurol Clin, Rome, Italy Univ Rome La Sapienza Rome Italy La Sapienza, Neurol Clin, Rome, Italy
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 169, anno: 1999,
pagine: 98 - 107
SICI:
0022-510X(19991031)169:1-2<98:TEORIA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC BRAIN-STIMULATION; MOTOR CORTEX; CORTICOCORTICAL INHIBITION; EXCITABILITY; GLUTAMATE; NEURONS; EXCITATION; DISORDERS; THERAPY; DISEASE;
Keywords:
amyotrophic lateral sclerosis; motor evoked potential; silent period; paired magnetic stimulation; riluzole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Desiato, MT Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Osped S Eugenio, Piazzale Umanesimo, I-00143 Rome, Italy Univ Roma Tor VergataPiazzale Umanesimo Rome Italy I-00143 y
Citazione:
M.T. Desiato et al., "The effect of riluzole in amyotrophic lateral sclerosis: a study with cortical stimulation", J NEUR SCI, 169(1-2), 1999, pp. 98-107

Abstract

A population of 31 patients with sporadic amyotrophic lateral sclerosis (ALS) was selected for a prospective open study based on treatment with riluzole. A neurophysiological evaluation was performed by means of single and paired transcranial magnetic stimulation (TMS). The examined parameters, excitability threshold, motor evoked potential (EP) duration, silent period (SP) duration and time course of intracortical inhibition to paired TMS after6 months treatment, were matched against those recorded from the patients themselves before the beginning of treatment and from 20 (single TMS) or 10(paired TMS) age-matched control subjects. Normal behaviour of the SP in response to increasing TMS was found in the treated patients; they showed a significant linear correlation between these two parameters (r = 0.96) comparable to that calculated for controls (r = 0.98), and significantly different with respect to drug-free patients (r = 0.8, P = 0.014). A significant reduced size of the 'conditioned' MEPS to paired stimulation was documentedin the treated patients compared with the untreated patients (P = 0.002). Our neurophysiological contribution to the assessment of the effect of riluzole on the motor cortical inhibitory property in ALS may be considered a setting for controlled trials in extended patient series, even in a pre-clinical phase. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:24:58