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Titolo:
Evidence that melanocortin 4 receptor mediates hemorrhagic shock reversal caused by melanocortin peptides
Autore:
Guarini, S; Bazzani, C; Cainazzo, MM; Mioni, C; Ferrazza, G; Vergoni, AV; Schioth, HB; Wikberg, JES; Bertolini, A;
Indirizzi:
Univ Modena & Reggio Emilia, Pharmacol Sect, Dept Biomed Sci, I-41100 Modena, Italy Univ Modena & Reggio Emilia Modena Italy I-41100 , I-41100 Modena, Italy Univ Uppsala, Dept Pharmaceut Pharmacol, S-75105 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75105 t Pharmacol, S-75105 Uppsala, Sweden Melacure Therapeut AB, Uppsala, Sweden Melacure Therapeut AB Uppsala Sweden cure Therapeut AB, Uppsala, Sweden
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 3, volume: 291, anno: 1999,
pagine: 1023 - 1027
SICI:
0022-3565(199912)291:3<1023:ETM4RM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTH-INDUCED REVERSAL; MOLECULAR-CLONING; CARDIOVASCULAR FUNCTION; ACUTE HYPOVOLEMIA; GAMMA-MSH; ACTH-(1-24); RATS; ADRENOCORTICOTROPIN; BLOOD; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Guarini, S Univ Modena & Reggio Emilia, Pharmacol Sect, Dept Biomed Sci, Via G Campi 287, I-41100 Modena, Italy Univ Modena & Reggio Emilia Via G Campi 287 Modena Italy I-41100
Citazione:
S. Guarini et al., "Evidence that melanocortin 4 receptor mediates hemorrhagic shock reversal caused by melanocortin peptides", J PHARM EXP, 291(3), 1999, pp. 1023-1027

Abstract

Melanocortin peptides are known to be extremely potent in causing the sustained reversal of different shock conditions, both in experimental animals and humans; the mechanism of action includes an essential brain loop. Threemelanocortin receptor subtypes are expressed in brain tissue: MC3, MC4, and MC5 receptors. In a volume-controlled model of hemorrhagic shock in anesthetized rats, invariably causing the death of control animals within 30 minafter saline injection, the i.v. bolus administration of the adrenocorticotropin fragment 1-24 (agonist at MC4 and MC5 receptors) at a dose of 160 mug/kg i.v. (54 nmol/kg) produced an almost complete and sustained restoration of cardiovascular and respiratory functions. An equimolar dose of gamma(1)-melanocyte stimulating hormone (selective agonist at MC3 receptors) was completely ineffective. The selective antagonist at MC4 receptors, HS014, although having no influence on cardiovascular and respiratory functions perse, dose-dependently prevented the antishock activity of adrenocorticotropin fragment 1-24, with the effect being complete either at the i.v. dose of200 mg/kg or at the i.c.v. dose of 5 mg/rat (17-20 mg/kg). We concluded that the effect of melanocortin peptides in hemorrhagic shock is mediated by the MC4 receptors in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:25:29